Research in the Sen laboratory focuses on basic mechanism of steroid hormone signaling and its association with disease development. A primary emphasis is on studies involving women’s health, specifically on ovarian physiology in the context of female fertility and liver metabolism related to non-alcoholic fatty liver disease. Most recently, we have also turned our attention towards understanding steroid-induced epigenetic modifications in the developmental origins of diseases. We are trying to understand how prenatal exposure to steroids and hormones in the form of maternal/fetal pathologies, nutritional deficits/excess and lifestyle choices/stress re-program the epigenome that in turn alters the developmental course of the fetus or offspring leading to long-term harmful outcomes that often culminate in adult pathologies. Our studies span a range of disciplines that ultimately link steroid signaling, molecular biology and physiology-in other words we study Steroid Biology. An important goal of the laboratory is to do research that helps us identify detailed mechanisms of steroid-induced diseases using animal and cell models and then translate these findings to the clinic. Our laboratory uses a wide range of mouse models, primary cell culture and cell lines as well as cell and molecular techniques, omics and physiological tools. We hope that by advancing our knowledge into the basic molecular mechanism of steroid actions we will come closer to understand how steroids may affect women’s health, and therefore be better equipped to identify new preventions or treatments.

Interdisciplinary Science and Technology Building
The Sen Lab is located in the Interdisciplinary Science and Technology Building (ISTB), left.