Yuan Wang

Assistant Professor, Stem Cell Biology & Developmental Biology

Yuan Wang

Telephone: 517-353-1416


B270A Anthony Hall

Department of Animal Science


  • Bachelor in Medicine, Shangdong Medical University, China
  • MS, Chinese Academy pf Preventive Medicine, China
  • PhD, Boston University, USA
  • Post-doc, Harvard Medical School and NIEHS


75% Research, 20% Teaching, 5% Extension


My main research focus is to dissect mammalian genetic programs that govern germ cell development. I am also interested in the regulatory events that affect pluripotency and differentiation of stem cells. Empowered with iPSC (induced pluripotent stem cells) technology, in vivo mouse knockout models, and long-term in vitro culture system of spermatogonial stem cells, my laboratory aims to understand underlying pathology of human male infertility.

Laboratory: Stem Cell Biology

Selected Publications

  1. Gong X, Chao R, Wang P, Huang X, Zhang J, Zhu X, Zhang Y, Yang X, Hou C, Ji X, Shi T & Wang Y*. (2016) Interplay of transcription factors and microRNAs during embryonic hematopoiesis, Sci China Life Science  Epub of print.
  2. Zhang J, Wang Q, Wang M, Jiang M, Wang YS, Sun Y, Xie TR, Wang J, Tang N, Song H, Chao R, Chen X & Wang Y*. (2016) GASZ and MFN-mediated mitochondrial functions are crucial for spermatogenesis, EMBO Rep 17:220-34
  3. Chao R, Gong X, Wang L, Wang P & Wang Y*. (2015) CD71high  population represents primitive erythroblasts derived from mouse embryonic stem cells, Stem Cell Res 14 (1):30-38
  4. Chu M, Wang L, Wang H, Ni T, Zhu J & Wang Y*. (2014) A novel role for CDX1 in embryonic epicardial development, PLoS ONE  9 (7): e103271
  5. Zhang X, Li B, Li W, Ma L, Zheng D, Li L,Yang W, Chu M, Chen W, Mailman R, Zhu J, Fan G,  Archer TK & Wang Y*. (2014) Transcriptional repression by BRG1-SWI/SNF complex affects pluripotency of human embryonic stem cells, Stem Cell Reports 3:460-474
  6. Wang Q, Liu XQ, Tang N, Archambeault D, Li J, Song H, Tang C, He B, Matzuk M & Wang Y*.  (2013)  GASZ promotes germ cell derivation from embryonic stem cells. Stem Cell Res 11(2):845-860
  7. Wang Y, Yabuuchi A, McKinney-Freeman S, Ducharm, Ray M, Chawengsaksophak K, Trevor Archer & Daley GQ. (2008) Cdx gene deficiency compromises embryonic hematopoiesis in the mouse, PNAS 105: 7756-61
  8. Wang Y, Yates F, Naveiras O, Ernst P & Daley GQ.  (2005) Embryonic stem cell-derived hematopoietic stem cells.  PNAS 102(52):19081-6.
  9. Davidson AJ, Ernst P, Wang Y, Dekens MPS, Kinglsey PD, Palis J, Korsmeyer SJ, Daley GQ & Zon LI. (2003) Cdx4 mutants fail to specify haematopoietic progenitors during embryogenesis and can be rescued by multiple hox genes. Nature 425(6955): 300-6.
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