College of Agriculture & Natural Resources Reproductive and Developmental Sciences Program

Education/Degree Information

Jose Teixeira received his B.S. in 1986 from the Massachusetts Institute of Technology and his Ph.D. in 1994 from the University of Massachusetts Medical School in Worcester, MA. Following his post-doctoral training at the Department of Surgery, at Massachusetts General Hospital and Harvard Medical School in Boston, MA, he was appointed as an Assistant Professor. He then became an Investigator in the Vincent Center for Reproductive Biology with the rank of Associate Professor in the Department of Obstetrics, Gynecology, and Reproductive Biology at Massachusetts General Hospital and Harvard Medical School. He was also a Principal Investigator in the Harvard Stem Cell Institute and an affiliate member of both the MGH Cancer Center and the Dana Farber Harvard Cancer Center. He is currently a Professor in the Department of Obstetrics, Gynecology and Reproductive Biology in the College of Human Medicine at Michigan State University.

Research Interests

We are interested in studying reproductive tract and gonadal developmental with major research interests focused on complementary studies directly related to women\'s health and reproduction. We use multi-omic approaches with both human and mouse models of disease to understanding the mechanisms induced in myometrial cells that we believe might be an underlying cause of uterine fibroid development and growth. We are also interested in the identification and molecular characterization of myometrial stem/progenitor cells and the functional effects of endocrine disruption on their behavior during uterine development and during normal uterine functions.

Recent Publications

1. Patterson AL, George J, Chatterjee A, Carpenter T, Wolfrum E, Pru JK, Teixeira JM. Label-retaining, putative mesenchymal stem cells contribute to repair of the myometrium during uterine involution. Stem Cells Dev. 2018 Oct 17. doi: 10.1089/scd.2018.0146. [Epub ahead of print] PMID: 30328770

2. George JW, Fan H, Johnson B, Carpenter TJ, Foy KK, Chatterjee A, Patterson AL, Koeman J, Adams M, Madaj ZB, Chesla D, Marsh EE, Triche TJ, Shen H, Teixeira JM. Integrated Epigenome, Exome, and Transcriptome Analyses Reveal Molecular Subtypes and Homeotic Transformation in Uterine Fibroids. Cell Rep. 2019 Dec 17;29(12):4069-4085.e6. doi: 10.1016/j.celrep.2019.11.077. PubMed PMID: 31851934; PubMed Central PMCID: PMC6956710.

3. Wilson MR, Reske JJ, Holladay J, Wilber GE, Rhodes M, Koeman J, Adams M, Johnson B, Su RW, Joshi NR, Patterson AL, Shen H, Leach RE, Teixeira JM, Fazleabas AT, Chandler RL.ARID1A and PI3-kinase pathway mutations in the endometrium drive epithelial transdifferentiation and collective invasion. Nat Commun. 2019 Aug 7;10(1):3554. doi: 10.1038/s41467-019-11403-6. PubMed PMID: 31391455; PubMed Central PMCID: PMC6686004.

4. Patterson AL, George JW, Chatterjee A, Carpenter TJ, Wolfrum E, Chesla DW, Teixeira JM.Putative human myometrial and fibroid stem-like cells have mesenchymal stem cell and endometrial stromal cell properties. Hum Reprod. 2020 Jan 1;35(1):44-57. doi: 10.1093/humrep/dez247. PubMed PMID: 31913469; PubMed Central PMCID: PMC6993861.

Reviews and Chapters

1. Teixeira J, Maheswaran S, and Donahoe, PK. Mullerian inhibiting substance: an instructive developmental hormone with diagnostic and possible therapeutic applications. Endocr Rev (2001) 22: 657-74. PMID11588147

2. Teixeira J, Rueda BR and Pru JK. Uterine Stem cells (September 30, 2008), StemBook, ed. The Stem Cell Research Community, StemBook, doi/10.3824/stembook.1.16.1, http://www.stembook.org. PMID20614602

3. Commandeur AE, Styer AC, Teixeira JM. Epidemiological and genetic clues for molecular mechanisms involved in uterine leiomyoma development and growth. Hum Reprod Update 2015 Sep;21(5):593-615. doi: 10.1093/humupd/dmv030. Epub 2015 Jul 3. PMID26141720; PMC4533663.

1. Dubeau L, Teixeira J. Origins of Epithelial Ovarian Cancer (2017) In: Translational Advances in Gynecological Cancers, Eds: Birrer MJ and Ceppi L. Academic Press, Cambridge MA.

2. Narang K, Cope Z, Teixeira JM. Developmental Genetics in the Female Reproductive Tract (2018) In: Human Reproductive and Prenatal Genetics, Eds: Leung P and Qiao J. Academic Press, Cambridge MA.

NCBI Publications