CV Hoffmann

Hanne M. Hoffmann, Ph.D.

Assistant Professor

ANIMAL SCIENCE

MICHIGAN STATE UNIVERSITY

474 S. Shaw Lane

1230H Anthony Hall

East Lansing, MI 48824

OFFICE: (517) 353-1415 / LAB: (517) 353-7112

HANNE@MSU.EDU

https://www.canr.msu.edu/hoffmann/

www.linkedin.com/in/hannehoffmann

 

EDUCATION

Bachelor          06/2005            Animal Physiology       Montpellier University 2, France

Masters             07/2007           Biology and Health       Montpellier University 2, France

Ph.D.               12/2010           Neurobiology               Montpellier University 2, France, European mention

Ph.D.               12/2010           Biochemistry                Autonomous University of Barcelona, Spain, Cum Laude

Dissertation: Evidence of histamine H3 receptor crosstalk with dopamine D1 receptors and group 1 metabotropic glutamate receptors in the brain: possible link with cocaine addiction-like behavior in rodents.

 

APPOINTMENTS

3/18-current    Assistant Professor, Animal Science, Michigan State University

04/17-2/18      Assistant Project Scientist III, Department of Reproductive Medicine, UC San Diego.

                       Supervisor Dr. Pamela L. Mellon, Ph.D.

06/11-03/17    Postdoctoral Scholar, Department of Reproductive Medicine, UC San Diego.

                       Supervisor Dr. Pamela L. Mellon, Ph.D.

                      

HONORS AND AWARDS

2005    Bachelor grant from Heinrich Hoffmann og Hustrus Mindefond (Denmark, 18 months)

2005    Bachelor grant from “Sønderjylland” (Denmark, 6 months)

2006    Erasmus travel grant from the European Union (European Union, 7 months)

2010    Travel grant for the annual meeting of the Society for Neuroscience in San Diego from Heinrich Hoffmann og Hustrus Mindefond (Denmark)

2014    Early Career Forum Travel award for ICE/ENDO 2014 in Chicago, IL (Women in Endocrinology)

2015    Endocrine Society Outstanding Abstract Award (ENDO 2015)

2016    Neena Schwartz Young Investigator Award in Basic Science (Women in Endocrinology)

2016    Early Investigators Award supported by Merck & Co., Inc. (Endocrine Society)

2017    New Investigator Award (Society for Behavioral Neuroendocrinology)

2018    Eugenia Rosenberg Abstract Travel Award (ENDO 2018). Declined

2019    Nominated for the Frank A. Beach New Investigator Award (Society for Behavioral Neuroendocrinology). Awaiting response

 

RESEARCH GRANTS

2007    Allocation de Recherche, Ph.D. fellowship from the French Ministry of Education (France, 2007-2010)

2016    K99 HD084759-01. K99/R00 Pathway to Independence award from NICHD (2016-2018). The Role of the Homeoprotein Vax1 in Fertility and Circadian Rhythm. Role: PI

2017    UC San Diego Frontiers of Innovation Scholars Program (FISP) Proposal 3-U3021 (2017-2018).  Determine the role of the transcription factor VAX1 in establishing the neuronal circuit regulating pubertal onset and fertility. Role: PI

2017    UC San Diego Frontiers of Innovation Scholars Program (FISP) Proposal 3-U3047 (2017-2018). Circadian modulation of histamine receptor-mediated synaptic transmission. Role: PI

2018    R00 HD084759-01. K99/R00 Pathway to Independence award from NICHD (2018-2021). The Role of the Homeoprotein Vax1 in Fertility and Circadian Rhythm. Role: PI

2018    USDA National Institute of Food and Agriculture, Hatch project 1018024 (2018-2023). Seasonal changes in neuroendocrine control of reproduction. Role: PI

2019    5-FY19-111, March of Dimes Basil O'Connor Starter Scholar Research Award (2019-2021). Deciphering the role of melatonin in the regulation of uterine function. Role: PI

 

PROFESIONAL MEMBERSHIPS

Society for Neuroscience (SFN)

Association for Women in Science (AWIS) and AWIS San Diego

The Endocrinology Society

Women in Endocrinology

Society for Behavioral Neuroendocrinology (SBN)

 

Publications

  1. Navarro G, Ferre S, Cordomi A, Moreno E, Mallol J, Casado V, Cortes A, Hoffmann H, Ortiz J, Canela EI, Lluis C, Pardo L, Franco R, Woods AS (2010). Interactions between intracellular domains as key determinants of the quaternary structure and function of receptor heteromers. J Biol Chem. Aug 27;285(35):27346-59. PMID: 20562103
  2. Moreno E, Hoffmann H, Gonzalez-Sepulveda M, Navarro G, Casado V, Cortes A, Mallol J, Vignes M, McCormick PJ, Canela EI, Lluis C, Moratalla R, Ferre S, Ortiz J, Franco R (2011). Dopamine D1-histamine H3 receptor heteromers provide a selective link to the map-kinase signalling in gabaergic neurons of the direct striatal pathway. J Biol Chem. Feb 18;286(7):5846-54. PMID: 21173143
  3. Hoffmann HM, Nadal R, Vignes M, Ortiz J. Chronic cocaine self-administration modulates ERK1/2 and CREB responses to dopamine receptor agonists in striatal slices. Addict Biol. 2011; 17, 565–575 PMID: 21812869
  4. González-Sepúlveda M, Rosell-Villar S,* Hoffmann HM,* Castillo-Ruiz M, Mignon V, Moreno-Delgado M, Vignes M, Díaz J, Sabriá J, Ortiz J. Cellular distribution of the histamine H3 receptor in the basal ganglia: Functional modulation of dopamine and glutamate neurotransmission. Basal Ganglia. 2013 July; 3(2):109-121
  5. Witham EA, Meadows JD, Hoffmann HM, Shojaei S, Coss D, Kauffman AS, Mellon PL.
    Kisspeptin regulates gonadotropin genes via immediate early gene induction in pituitary gonadotropes. Mol Endocrinol. 2013 Aug;27(8):1283-94. PMID: 23770611
  6. Moreno E, Moreno D, Navarro G, Hoffmann HM, Fuentes S, Rosell-Vilar S, Gasperini P, Rodriguez-Ruiz M, Medrano M, Mallol J, Cortes A, Casado V, Lluis C, Ferre S, Ortiz J, McCormick P, and Canela E. Cocaine disrupts histamine H3 receptor modulation of dopamine D1 receptor signaling: sigma1-D1-H3 receptor complexes as key targets for reducing cocaine's effects. J Neurosci. 2014 Mar 5;34(10):3545-58. PMID: 24599455
  7. Hoffmann HM, Tamrazian A, Xie H, Pérez-Millán MI, Kauffman AS, Mellon PL. Heterozygous Deletion of Ventral Anterior Homeobox (Vax1) Causes Subfertility in Mice. Endocrinology 2014 Oct;155(10):4043-53. PMID:25060364
  8. Xie H, Hoffmann HM,* Meadows JD,* Mayo SL, Trang C, Leming SS, Maruggi C, Davis SW, Larder R, Mellon Homeodomain Proteins SIX3 and SIX6 Regulate Gonadotrope-specific Genes During Pituitary Development. Mol Endocrinol. 2015 Jun;29(6):842-55. PMID: 25915183
  9. Hoffmann HM, Trang C, Gong P, Kimura I, Pandolfi EC, and Mellon PL. Deletion of Vax1 from Gonadotropin-Releasing Hor­mone (GnRH) Neurons Abolishes GnRH Expression and Leads to Hypogonadism and Infertility. J Neurosci. 2016 Mar 23;36(12):3506-18. PMID: 27013679
  10. Hoffmann HM, Crouzin N, Moreno E, Raivio N, Fuentes S, McCormick PJ, Ortiz J and Vignes M. Long-lasting impairment of mGluR5-activated intracellular pathways in the striatum after withdrawal of cocaine self-administration. Int J Neuropsychopharmacol. 2016 Oct 15. PMID: 27744406
  11. Hoffmann HM#, Gong P, Tamrazian A, and Mellon PL. Transcriptional interaction between cFOS and the homeodomain-binding transcription factor VAX1 on the GnRH promoter controls Gnrh1 expression levels in a GnRH neuron maturation specific manner. Mol Cell Endocrinol. 2017 Sep 7. PMID:28890143
  12. Xie H*, Hoffmann HM*, Iyer AK, Brayman MJ, Ngo C, Sunshine MJ, and Mellon PL. Chromatin status and transcription factor binding to gonadotropin promoters in gonadotrope cell lines. Reprod Biol Endocrinol. 2017 Oct 24. PMID:29065928
  13. Pandolfi EC, Hoffmann HM, Schoeller EL, Mellon PL. Haploinsufficiency of SIX3 Abolishes Male Reproductive Behavior through Disrupted Olfactory Development, and Impairs Female Fertility through Disrupted GnRH Neuron Migration.  Molecular Neurobiology. 2018; 55, 8709-8727. PMID: 29589282
  14. Hoffmann HM#. Determination of reproductive competence by confirming pubertal onset and performing a fertility assay in mice and rats. J Vis Exp. 2018 Oct 13;(140). PMID: 30371660
  15. Hoffmann HM*, Larder R*, Lee JS, Hu RJ, Trang C, Devries BM, Clark DD, and Mellon PL. Differential CRE expression in Lhrhcre and Gnrhcre mouse lines and the impact on fertility deleting the transcription factor Otx2. 2019, 108, 328-342. PMID: 30739114
  16. Pandolfi EC, Tonsfeldt KJ, Hoffmann HM, Mellon PL. Deletion of the Homeodomain Protein Six6 from GnRH Neurons Decreases GnRH Gene Expression Resulting in Infertility. 2019. 160, 2151-2164. PMID:31211355.
  • Featured article in Endocrinology (June 27, 2019)
  1. Pandolfi EC, Breuer JA, Huu VAN, Talluri T, Nguyen, D, Lee JS, Hu R, Bharti K, Skowronska-Krawczyk D, Gorman MR, Mellon PL, Hoffmann HM#.(2019). The Homeodomain Transcription Factors Vax1 and Six6 are Required for SCN Development and Function. Molecular Neurobiology. [In press]
  2. Yaw AM*, Duong T*, Nguyen D, and Hoffmann HM#. Pregnancy impacts circadian rhythms in the mouse reproductive axis [Submitted]  
  3. Hoffmann HM*#, Meadows JD*, Breuer JA, Devries BM, Yaw AM, Oosterhouse HJ, Chen A, Trang C, Sora JL, Gorman MR, Welsh DK, Mellon PL. Post-developmental weakening of the SCN network mis-aligns circadian rhythm synchrony in the reproductive axis impairing the LH surge and female fertility [In preparation]

 

* Authors contributed equally to the work

# Corresponding author

 

Invited publications and book chapters

  1. Hoffmann HM# and Mellon PL. A small population of neurons govern fertility: the critical role of VAX1 in GnRH neuron development and fertility maintenance. Invited research highlight for Neuroscience Communications. Neurosci Commun (Houst). 2016;2. pii: e1373. PMID: 28164172
  2. Hoffmann HM and Mellon PL. Regulation of GnRH gene expression. Book chapter in The GnRH neuron and its Control edited by Allan Herbison and Tony Plant. John Wiley & Sons. Feb 19, 2018
  1. Hoffmann HM*, Larder R*, Pandolfi EC*, Mellon PL. Haploinsufficiency of Homeodomain Proteins Six3, Vax1, and Otx2, Causes Subfertility in Mice Via Distinct Mechanisms. 2019;109(3):200-207. PMID: 30261489
  2. Sen A, Hoffmann HM#. Role of cell endogenous circadian rhythms in synchronizing hormone release in the hypothalamic-pituitary-gonadal axis. [Submitted]

 

* Authors contributed equally to the work

# Corresponding author

 

INTERVIEWS and in the news

  1. Interview “Two minutes with: Hanne Hoffmann on new techniques for behavior”, BioTechniques, Nov 23, 2018. https://www.biotechniques.com/omics/two-minutes-with-hanne-hoffmann-on-new-techniques-for-behavior/
  2. Interviewed to comment on “This Small Norwegian Island, Where The Sun Doesn’t Set For 69 Days, Wants To Abolish Time” written by Natasha Ishak. Ati June 20, 2019. https://allthatsinteresting.com/sommaroy-island-abolish-time

 

Services

  • Associate Faculty of Faculty of 1000 (2016-2019)
  • Editorial board of Molecular and Cellular Endocrinology (2018-current)
  • Peer reviewer for: Molecular and Cellular Endocrinology (2017-current), PLOS ONE (2017-current), Experimental Physiology (2019-current), European Journal of Cell Biology (2019-current)
  • Moderator of oral session entitled “Enriching Human Life and Society I” (Graduate Student and Postdocs), at the UC San Diego Frontiers of Innovation Scholars Program (FISP) Symposium, UC San Diego (October 31, 2017) 
  • Chair of symposium “Circadian and seasonal changes in brain function and behavior”, at the Society for Behavioral Neuroendocrinology-International Congress of Neuroendocrinology. Toronto Canada (SBN/ICN, July 2018)
  • Judge: Three Minute Thesis Competition sponsored by the Endocrine Society at the Society for Behavioral Neuroendocrinology-International Congress of Neuroendocrinology. Toronto Canada (SBN/ICN, July 2018)
  • Chair of nanosymposium: "Advances in Molecular, Genetic, and Imaging Techniques". Neuroscience 2018 San Diego, CA (SFN 2018)
  • Judge at the 10th Annual Animal Science Undergraduate Research Forum (ASURF) at Michigan State University (April 12, 2019)
  • Poster judge at the Symposium on the Neurobiology of Motivated Behavior, Michigan State University (May 16, 2019) 
  • Organizer of 10th Annual Michigan Alliance for Reproductive Technologies and Sciences (MARTS). Michiana State University, East Lansing, MI (May 31, 2019)
  • Department Advisory Committee, Department of Animal Science, MSU (August 2019-current)
  • Poster judge at the Annual Research Day for the Reproductive and Developmental Science Program (MSU). Portland, MI (Sep 26, 2019) 

Oral communicationS

2010    Hanne M. Hoffmann, Michel Vignes, Jordi Ortiz. Crosstalk of histamine H3 receptors and metabotropic glutamate 5 receptors regulates synaptic transmission in the brain. Simposi de neurobiologia experimental, Societat Catalana de Biologia (October 2010, Barcelona, Spain).

2014    Hanne M. Hoffmann, Anika Tamrazian, Pamela L. Mellon. Vax1 heterozygous mice exhibit male and female subfertility: Central versus peripheral origins. Poster Preview Presentation at ICE/ENDO 2014 (Endocrine Society), Chicago, IL (June 2014, USA).

  • Selected for the Presidential Poster Competition
  • Recipient of the Early Career Forum Travel award by Women in Endocrinology

2015    Hanne M. Hoffmann, Ikuo Kimura, Ping Gong, Crystal Trang, Alexander S. Kauffman, Pamela L. Mellon. Absence of Vax1 in GnRH neurons abolishes GnRH expression and leads to hypogonadism: Investigating the role of the homeoprotein, Vax1, in GnRH neuron maturation. ENDO 2015 (Endocrine Society), San Diego, CA (March 2015). 

  • Recipient of 2015 Endocrine Society Outstanding Abstract Award

2016    Hanne M. Hoffmann, Jason D. Meadows, Crystal Trang, Brittainy Hereford, Kapil Bharti, Michael R. Gorman, Pamela L. Mellon. Deletion of SIX3 or VAX1 in the SCN impairs circadian rhythms and fertility. ENDO 2016 (Endocrine Society), Boston, MA (March 2016).

  • Recipient of the 2016 Neena Schwartz Young Investigator Award in Basic Science
  • Recipient of the 2016 Early Investigators Award supported by Merck & Co., Inc.

2017    Hanne M. Hoffmann, Jessica S. Lee, Jason D. Meadows, Crystal Trang, Haley J. Oosterhouse, Erica C. Pandolfi, Michael R. Gorman, David K. Welsh, Pamela L. Mellon. Circadian and neuroendocrine control of reproduction. Society for Behavioral Neuroendocrinology (Long Beach, CA, June 2017)

  • Recipient of the 2017 New Investigator Award from the Society for Behavioral Neuroendocrinology

2018    Hanne M. Hoffmann, Erica C. Pandolfi, Jessica S. Lee, Rachael J. Hu, Crystal Trang, Viet A. Nguyen, Dorota Skowronska-Krawczyk, Michael R. Gorman, Pamela L. Mellon. The importance of characterizing Cre-alleles: a comparative study of the impact of neuronal development and behavior in mice with conditional deletion of the homeodomain transcription factors Six6 and Vax1 using two different Gnrh-promoter driven Cre-alleles. Society for Neuroscience (SFN, San Diego, CA, November 2018)

 

Invited presentations

2014    Hanne M. Hoffmann.  Rhythms, hormones and fertility. CCB Fall Workshop on Biological Timing, San Diego, CA (November 2014).

2018    Hanne M. Hoffmann. Circadian and Neuroendocrine Control of Reproduction. The 9th annual Michigan Alliance for Reproductive Technologies and Science (MARTS). Grand Rapids, MI (May 2018).

 

TEACHING

2016    Guest lecturer in the graduate Biology program at California State University, Fresno. Title: Deletion of the transcription factor Vax1 affects neuronal development and impairs fertility. Fresno, CA (May 2016).

2016    Assisting instructor in the graduate course NEU221 Advanced Topics in Neurosciences. UC San Diego (Fall 2016).

2018    Guest lecturer in the graduate Neuroscience program at Michigan State University. Title: Circadian Control of Neuroendocrine Rhythms and Reproduction. MSU, East Lansing, MI (October 2018).

2018-   Instructor ANS 409 “Advancements in Reproduction”.

 

Invited Seminars

2016    Reproductive Endocrinology Unit of the Department of Medicine, Harvard Medical School, Mass. General Hospital. Boston, MA (March 2016).

2016    Reproductive Medicine Retreat. UC San Diego, CA (Sep 2016).

2019    Tulane School of Medicine. New Orleans, LA (March 2019)

2019    University of Michigan. Ann Arbor, MI (June 2019)

2019    Translational Science Seminar Series. Michigan State University, Grand Rapids, MI (October 2019)

2019    C.S. Mott Center, Wayne State University, Detroit, MI (December 2019)

 

Posters

  • Valerie Compan, Hanne M. Hoffmann, V Mendizabal, Alexandra Jean, Gregory Conductier, Letitia Laurent, P. Berta, Rafael Maldonado, Joel Bockaert. Deletion of the serotonin 4 receptors differentially affects cocaine-induced anorexia, locomotor activity and CREB phosphorylation in the nucleus accumbens. 8th Colloque Montpellier (May 2007 France)
  • Hanne M. Hoffmann, Michel Vignes, Jordi Ortiz. Chronic cocaine self-administration alters ERK1/2 and CREB responses to dopamine receptor agonists. Society for Neuroscience 2010 (November 2010, San Diego USA)
  • Hanne M. Hoffmann, Ping Gong, Pamela L. Mellon. Involvement of cFos in ventral anterior homeobox 1 regulation of gonadotropin-releasing hormone transcription in maturing gonadotropin-releasing hormone neurons. Society for Neuroscience 2012, New Orleans (October 2012, USA)
  • Hanne M. Hoffmann, Ikuo Kimura, Ping Gong, Anika Tamrazian, Alexander S. Kauffman, Pamela L. Mellon. Vax1 is required for generation of hypothalamic GnRH Neurons, GnRH Gene Expression, and normal reproductive function in mice. Society for Neuroscience 2013, San Diego (November 2013, USA)
  • Erica C. Pandolfi, Hanne M. Hoffmann, Jason D. Meadows, Pamela L. Mellon. The Homeodomain Protein, Six3 is Important in the Development of GnRH Neurons in Mice. ICE/ENDO 2014 (Endocrine Society), Chicago, IL (June 2014, USA)
  • Hanne M. Hoffmann, Anika Tamrazian, Pamela L. Mellon. Vax1 heterozygous mice exhibit male and female subfertility: Central versus peripheral origins. ICE/ENDO 2014 (Endocrine Society), Chicago, IL (June 2014, USA)
  • Hanne M. Hoffmann, Jason D. Meadows, Crystal Trang, Brittainy Hereford, Haley Oosterhouse, Kapil Bharti, Michael R. Gorman, Pamela L. Mellon. Deletion of SIX3 or VAX1 in the SCN impairs circadian rhythms and fertility. CCB symposium: From Cells to Clinic, Center for Circadian Rhythms, San Diego (February 2016)
  • Erica C. Pandolfi, Hanne H. Hoffmann, Erica L. Schoeller, Pamela L. Mellon. The Homeodomain Gene Six3 Is important in GnRH Neuron Migration and Olfaction in Mice. Systems Biology of Reproduction (July 2016, USA). Society for the Study of Reproduction, San Diego (July 2016, USA)
  • Erica C. Pandolfi, Hanne M. Hoffmann, Erica L Schoeller, Pamela L Mellon. (2016). Haploinsufficiency of the homeodomain protein Six3 abolishes male reproductive behavior through disrupted olfactory epithelium development and impaired GnRH neuron migration. The Society for Neuroscience Annual Meeting. San Diego (November 2016, USA)
  • Hanne M. Hoffmann, Crystal Trang, Brittainy Hereford, Kapil Bharti, Michael R. Gorman, David K. Welsh, Pamela L. Mellon. Ventral Anterior Homeobox 1 is Required for Suprachiasmatic Nucleus Development as well as Circadian Output in Adulthood Allowing Female Fertility. The Society for Neuroscience Annual Meeting, San Diego (November 2016, USA).
  • Erica C. Pandolfi, Hanne M. Hoffmann, Erica L. Schoeller, Pamela L. Mellon. The Importance of Six3 and Six6 Homeodomain Genes in GnRH Neuron Development, Olfaction, and Fertility. Society for the Study of Reproduction (July 2017, Washington DC, USA).
    • Oral presentation Erica C. Pandolfi
  • Hanne M. Hoffmann, Joseph A. Breuer, Jessica S. Lee, Jason D. Meadows, Michael R. Gorman, David K. Welsh, and Pamela L. Mellon. Females Require Circadian Alignment of Reproductive Tissues to Maintain Fertility. 12th Annual Salk Institute, Foundation IPSEN and Science Symposium on Biological Complexity. (January 2018, La Jolla, CA).
  • Hanne M. Hoffmann, Erica C. Pandolfi, Rachel Larder, Jessica S. Lee, Rachael J. Hu, Crystal Trang, Daniel D. Clark, Michael R. Gorman, Pamela L. Mellon. Significant differences in fertility and circadian behavior due to deletion of the homeodomain transcription factors Six6, Vax1, or Otx2 using two different GnRH-cre mouse lines. ENDO 2018 (March 2018, Chicago, IL).
    • Selected for presidential poster competition (declined).
  • Pamela L. Mellon, Erica C. Pandolfi, Hanne M. Hoffmann. The Roles of Homeodomain Proteins in GnRH Neuronal Development and Fertility. Neuroendocrinology-International Congress of Neuroendocrinology (July 2018, Toronto, Canada).
    • Invited speaker Pamela L. Mellon
  • Hanne M. Hoffmann, Joseph A. Breuer, Jessica S. Lee, Jason D. Meadows, Michael R. Gorman, David K. Welsh, Pamela L. Mellon. Circadian rhythm synchrony is required for estrous cycling and female fertility. Neuroendocrinology-International Congress of Neuroendocrinology (July 2018, Toronto, Canada).
  • Thu Duong, Duong Nguyen, Hanne M. Hoffmann. Elucidating the role of the circadian clock gene Bmal in myometrium function during pregnancy. Reproductive and Developmental Science Program Research Retreat, MSU (November 2018, Portland, MI)
  • Thu Duong, Duong Nguyen, Hanne M Hoffmann. Circadian rhythms of the uterine myometrium are involved in its daily changes in sensitivity to the labor promoting hormone oxytocin. 11th Annual Graduate Academic Conference, 16th February 2019 at the MSU Union in East Lansing, MI
    • Oral presentation by Thu Duong
  • Aierken Abudu, Sambit Roy, Olivia Nave, Jie Wang, Kevin Childs, Michael T. Sellix, Hanne M. Hoffmann, Aritro Sen. Androgen-Induced Disruption of the Biological Clock: The Link between PCOS and NAFLD. ENDO 2018 (March 2019, New Orleans, LA).
    • Outstanding poster award
  • Thu Duong, Duong Nguyen, Hanne M Hoffmann. Elucidating the role of the circadian clock gene Bmal in myometrium function during pregnancy. AAP/ASCI/APSA joint meeting 2019 (April 2019, Chicago, IL)
  • Thu Duong, Hanne M Hoffmann. Time-of-day impacts uterine contractility and drug efficacy. 14.th Annual Animal Science Graduate Research Forum. Michigan State University (October 2019)
    • Oral presentation by Thu Duong

 

 

PANELIST

2014    UCSD career seminar, “Learn at Lunch: Alumni Career Panel Women in Science (STEM)” at the UC San Diego’s Career Services Center. February 4, 2014.

2015    UCSD postdoc Health and Wellness series, “Working Postdoc with Small Children: How to Effectively Manage Your Two Jobs”. April 15, 2015.

2016    Panelist at the Center for Circadian Biology (CCB) Fall Workshop on Biological Timing. Professional Development Panel – Career advice and strategies for trainees. UC San Diego. November 11, 2016

2017    Panelist at the UCSD Postdoc Association “STEM Academic Job Search Panel”. UC San Diego. October 3, 2017.

2017    Panelist at the Center for Circadian Biology (CCB) Fall Workshop on Biological Timing. Professional Development Panel – F/K award grant tips. UC San Diego. November 17, 2017

 

OUTREACH AND COMMITTEES  

2005-2007        Treasurer at Xenope, association for biology students at Montpellier University, France.

2012-2016        Committee member of the Strategy Session, AWIS San Diego, CA.

2012                Expanding your horizon Univ. San Diego, presenting “The Chemistry of Beauty”
                        designed for a 7-9th grade audience.

2013-2015       Co-chair of the Strategy Session, AWIS San Diego.

2014-2018       Co-founder and member of the Circadian Trainees 7 (CT7) group at the Center for Circadian Biology at UC San Diego.

2014-2018        Volunteering at the UCSD outreach program “Society for Undergraduate Research and

Outreach” (SURO).

2015-2016       Mentor in the Mentor Assistance Program (MAP) at UC San Diego.

2015-current    Committee member of the Mentoring Committee at Women in Endocrinology.

2019-current    Chair of the Reproductive and Developmental Science Program Seminar Series, MSU.

2019-current    Committee member of the Department Advisory Committee, Department of Animal Science, MSU.

 

STUDENTS MENTORED

University of California San Diego (2011-2018)

  1. Ping Gong, UCSD Undergraduate Student (September 2011-August 2012)
    • Oral presentation at the 25th Annual UCSD Undergrad Research Conference (April 28, 2012, UCSD) entitled: Vax1 and cFos regulation of GnRH transcription changes during GnRH neuron maturation.
    • Poster presentation at the UCSD at Undergraduate meeting (2012)
    • Masters in Genetic Counseling, Berkley, CA (summer 2013-2015)
  2. Anika Tamrazian, UCSD Undergraduate and Masters’ Degree Student (April 2012-June 2014)
    • Obtained her Master’s degree titled “Ventral Anterior Homeodomain Protein Regulates

Gonadotropin-Releasing Hormone and Fertility” (June 2014)

  • Student at New York Optometry School (August 2014-Nov 2018)
  1. Genevieve E. Ryan, UCSD PhD Rotation Student (October 2012-Decemeber 2012)
    • Graduate student in the Mellon lab (summer 2013-June 2018)
    • Postdoc at UCSD (2018-current)
  2. Erica C. Pandolfi, UCSD PhD Rotation Student (July 2013-September 2013)
    • Graduate student in the Mellon lab (summer 2014-September 2018)
    • Postdoc at UCLA (2018-current)
  3. Crystal Trang, UCSD Undergraduate (July 2014-June 2015), Masters Student (July 2015-June 2016)
    • Summer Research Fellowship from The Endocrine Society (2015)
    • Summer Research Fellowship: Excellence in Research Award from Endocrinology (2016)
    • Obtained Master’s degree titled “The Transcription Factor VAX1 is Required for Normal Development and Function of GnRH Neurons and the SCN” (June 2016)
    • Touro School of Pharmacy (August 2016-current)
  4. Brittainy M. Hereford. Summer Student from University of Virginia (June-August 2015)
    • Short-Term Research Experience for Underrepresented Persons (STEP-UP) program at NIH-NIDDK
    • Annual Biomedical Research Conference for Minority Students (ABRCMS) Travel award (2015) and poster presentation.
  5. Haley J. Oosterhouse, UCSD Undergraduate Honors Senior Thesis Student (June 2015-June 2016)
    • Medical student at University of Southern California (August 2017-current)
  6. Rachael Hu, UCSD Undergraduate Student (January 2016-June 2017)
    • Doris A. Howell Foundation Research Scholarship for Women's Health. Summer Research Scholarship (2016)
  7. Joseph A. Breuer, UCSD Undergraduate Student (BISP199 June 2016-March 2017), Masters’ Student (April 2017-June 2018)
    • Poster presentation at the 2017 UC San Diego Frontiers in Innovation Scholars Program Symposium
    • Obtained Master’s degree titled “Homeodomain Transcription Factors VAX1 and SIX3 Modulate SCN Circadian Output” (June 2018)
  8. Jessica Sora Lee, Undergraduate Student (BISP199 June-December 2016), Masters’ Student (January 2017-December 2017)
    • Obtained Master’s degree titled “The Transcription Factor VAX1 is Required in Kisspeptin, But Not AVP, Neurons for Fertility” (December 2017)
  9. Austin Y Chin, Undergraduate Student (Volunteer January-May 2017, BIPS199 June 2017-March 2018)
    • Ledell Family Research for Science and Engineering. Summer Research Scholarship (2017) Declined
    • Poster presentation at the 2017 UC San Diego Frontiers in Innovation Scholars Program Symposium
  10. Sabrina Barreto. Summer student from Imperial Valley College, CA (June-August 2017)
    • Summer Training Academy for Research Success (STARS)
    • Poster presentation at the Annual Biomedical Research Conference for Minority Students (ABRCMS, 2017)

 

Michigan State University (2018-current)

Postdoctoral Scholars

  1. Alexandra Yaw. PhD from Kent State University. (June 17, 2019-current)
    1. NICHD T32 trainee (Oct 1, 2019-Sep 30, 2020)

Graduate Students

1.       Thu Van Quynh Duong. College of Osteopathic Medicine. DO/PHD program (Oct 2018-current)

 

Rotation Students

1.       Thu Van Quynh Duong. College of Osteopathic Medicine. DO/PHD program (Aug 2018-Sep 2018)

2.       Rabail Khan. Neuroscience Graduate program (Aug 2019-Dec 2019). Fulbright Scholar

 

Undergraduate Students

  1. Brooke Devries. Lyman Briggs undergraduate student (May 2018-current)
    • Poster presentation: Brooke M Devries, Hanne M Hoffmann. Comparison and validation of two Gonadotropin-releasing hormone-promoter driven Cre expressing mice. (East Lansing, April 2019). Poster presented at
      1. The Undergraduate Research and Arts forum at MSU
      2. The 2019 Lyman Briggs Research Symposium MSUFCU poster session.Honorable Mention Award
    • NEU490 Undergraduate Research, Neuroscience Program. MSU (3 credits, Fall 2019)

 

  1. Tulasi Talluri. Lyman Briggs undergraduate student (May 2018-current)
    • Summer Research Fellowship from The Endocrine Society (2019)
    • Poster presentation at the Undergraduate Research and Arts forum at MSU. Tulasi Talluri, Hanne M Hoffmann. Vax1 heterozyote mice have abnormal circadian rhythms which contribute to their poor fertility. (East Lansing, April 2019)
  2. Gloria Parisa Yarandi. Lyman Briggs undergraduate student (August 2018-October 2018)
  3. Muhammed Asad. Lyman Briggs undergraduate student (March 2019-current)
    • ANS492 Undergraduate Research, Animal Science (Fall 2019)
  4. Autumn Mclane-Svoboda. Mechanical/Biomedical Engineering undergraduate student (October 2019-current)
  5. Aneesh Sai Cherukuri. Lyman Briggs undergraduate student (October 2019-current)
    • Alumni Distinguished Scholarship recipient, MSU (2018)

 

LABORATORY TECHNICIANS AND LABORATORY MANAGERS (Michigan State University)

  1. Duong Nguyen. Laboratory Technician. (August 2018-current)

 

GRADUATE STUDENT COMMITEES

  1. Thu Duong, MSU DO-PhD program. Committee member, PI (2019-current)
  2. Brooke Armistead, MSU PhD. Committee member (2019-current)

 

TRAINING COURSES

2008    FENSEB Animal handling course, Barcelona (Autonomous University Barcelona, Spain)

2009    Science history (Montpellier University 2, France)

2012    Ethics and Survival Skills (UC San Diego)

2015    Scientific Ethics (UC San Diego)

2017    Pathways to Scientific Teaching (January and February 2017, UC San Diego)

2017    Academic Laboratory Management & Leadership Symposium from Torrey Pines Training Consortium (February 2017, San Diego)

2018    Optimization of Research Mentoring Outcomes. Online course entitled CTSI X100 - Optimizing the Practice of Mentoring. Course offered by the University of Minnesota.

2018    The Iceman’s Run: Advanced NIH Grantsmanship and Personal Coaching Program for Winning NIH Grants - Webinar Series (MSU September 20 – December 7). 

2019    Write Winning Grants (One day workshop, January 2019, MSU)

2019    College of Agriculture and Natural Resources  Mentoring Workshop for new faculty (One day workshop, January 2019, MSU)

2019    MSU Academic Communications Fellowship and Training Program (Sep 2019-Dec 2019)

 

LANGUAGES

  • Danish: spoken, read and written (mother tongue)
  • English: spoken, read and written (excellent)
  • Spanish: spoken, read and written (very good)
  • French: spoken, read and written (very good)
  • German: spoken and read (basic)

 

/hoffmann/CV_ H Hoffmann 2019.docx