Department of Animal Science Hoffmann Lab

Hanne M. Hoffmann, Ph.D.

Assistant Professor

DEPARTMENT OF ANIMAL SCIENCE

MICHIGAN STATE UNIVERSITY

Interdesciplinary Science and technology Building #3010

766 Service Road

East Lansing, MI 48824

OFFICE: (517) 353-1415 / LAB: (517) 353-7112

HANNE@MSU.EDU

https://www.canr.msu.edu/hoffmann/

www.linkedin.com/in/hannehoffmann

EDUCATION

Bachelor           06/2005            Animal Physiology        Montpellier University 2, France

Masters             07/2007            Biology and Health       Montpellier University 2, France

Ph.D.                12/2010            Neurobiology                Montpellier University 2, France, European mention

Ph.D.                12/2010            Biochemistry                Autonomous University of Barcelona, Spain, Cum Laude

Dissertation: Evidence of histamine H3 receptor crosstalk with dopamine D1 receptors and group 1 metabotropic glutamate receptors in the brain: possible link with cocaine addiction-like behavior in rodents.

APPOINTMENTS

06/11-03/17     Postdoctoral Scholar, Department of Reproductive Medicine, UC San Diego

                       Supervisor Dr. Pamela L. Mellon, Ph.D.

04/17-2/18       Assistant Project Scientist III, Department of Reproductive Medicine, UC San Diego

                       Supervisor Dr. Pamela L. Mellon, Ph.D.

3/18-current     Assistant Professor, Animal Science, Michigan State University (tenure-track)

HONORS AND AWARDS

2005     Bachelor grant from Heinrich Hoffmann og Hustrus Mindefond (Denmark, 18 months)

2005     Bachelor grant from “Sønderjylland” (Denmark, 6 months)

2006     Erasmus travel grant from the European Union (European Union, 7 months)

2010     Travel grant for the annual meeting of the Society for Neuroscience in San Diego from Heinrich Hoffmann og Hustrus Mindefond (Denmark)

2014     Early Career Forum Travel award for ICE/ENDO 2014 in Chicago, IL (Women in Endocrinology)

2015     Endocrine Society Outstanding Abstract Award (ENDO 2015)

2016     Neena Schwartz Young Investigator Award in Basic Science (Women in Endocrinology)

2016     Early Investigators Award supported by Merck & Co., Inc. (Endocrine Society)

2017     New Investigator Award (Society for Behavioral Neuroendocrinology)

2018     Eugenia Rosenberg Abstract Travel Award (ENDO 2018). Declined

2019     Selected and sponsored by the MSU Provost Office to participate in the 2019 Academic Communications Fellowship

2020     Selected and sponsored by the MSU Provost Office to participate in the Career and professional development workshop organized by the National Center for Faculty Development & Diversity Faculty Success Program 

2022     Burroughs Wellcome Fund Next Generation Pregnancy Initiative, Finalist (not awarded)

2022     2021 Biology of Reproduction Most Popular Research Article Award (Biology of Reproduction). Award in recognition of the manuscript entitled “Low CLOCK and CRY2 in 2nd Trimester Human Maternal Blood and Risk of Preterm Birth a Nested Case Control Study,” published in the October 2021 issue of BOR being selected as Biology of Reproduction’s most popular research article of 2021 based on Altmetric score.

GRANTS

2007     Allocation de Recherche, Ph.D. fellowship from the French Ministry of Education (France, 2007-2010).

2016     K99 HD084759-01. K99/R00 Pathway to Independence award from NICHD (2016-2018).

The Role of the Homeoprotein Vax1 in Fertility and Circadian Rhythm.

Role: PI

2017     UC San Diego Frontiers of Innovation Scholars Program (FISP) Proposal 3-U3021 (2017-2018). 

Determine the role of the transcription factor VAX1 in establishing the neuronal circuit regulating pubertal onset and fertility.

Role: PI

2017     UC San Diego Frontiers of Innovation Scholars Program (FISP) Proposal 3-U3047 (2017-2018).

Circadian modulation of histamine receptor-mediated synaptic transmission.

Role: PI

2018     R00 HD084759-01. R00 Pathway to Independence award from NICHD (2018-2021), Non-cost extension till 2023.

The Role of the Homeoprotein Vax1 in Fertility and Circadian Rhythm.

Role: PI

2018     USDA National Institute of Food and Agriculture, Hatch project MICL1018024 (2018-2023).

Seasonal changes in neuroendocrine control of reproduction.

Role: PI

2019     5-FY19-111, March of Dimes Basil O'Connor Starter Scholar Research Award (2019-2021).

Deciphering the role of melatonin in the regulation of uterine function.

Role: PI

2020     MSU College of Agriculture and Natural Resources Microgrant (2020-2021).

Support visit of collaborator of novel translational research project being developed at MSU.

Role: PI

2020     MSU Department of Animal Science, Collaborative Funding Initiative (2020-2023).

Establish the impact of room light on shelter cat wellbeing and adoptability.

Role: Co-PI

2022     MSU College of Agriculture and Natural Resources Microgrant (2022-2023).

Create a travel size teaching toolbox to enhance student learning and increase student engagement in the classroom and during outreach activities.

Role: PI

HUMAN RESEARCH

2020     ClinicalTrials.gov Identifier: NCT04521972. Impact of Room Light on Uterine Contractions and Labor Progression in Pregnancy. Michigan State University, East Lansing and McLaren East Lansing, MI. (MSU IRB approval complete, pending McLaren IRB approval)

PROFESIONAL MEMBERSHIPS

Society for Neuroscience (SFN)

The Endocrinology Society (ENDO)

Society for Behavioral Neuroendocrinology (SBN)

Society for Research on Biological Rhythms (SRBR)

Publications

1. Navarro G, Ferre S, Cordomi A, Moreno E, Mallol J, Casado V, Cortes A, Hoffmann H, Ortiz J, Canela EI, Lluis C, Pardo L, Franco R, Woods AS (2010). Interactions between intracellular domains as key determinants of the quaternary structure and function of receptor heteromers. J Biol Chem. Aug 27;285(35):27346-59. PMID: 20562103
2. Moreno E, Hoffmann H, Gonzalez-Sepulveda M, Navarro G, Casado V, Cortes A, Mallol J, Vignes M, McCormick PJ, Canela EI, Lluis C, Moratalla R, Ferre S, Ortiz J, Franco R (2011). Dopamine D1-histamine H3 receptor heteromers provide a selective link to the map-kinase signalling in gabaergic neurons of the direct striatal pathway. J Biol Chem. Feb 18;286(7):5846-54. PMID: 21173143
3. Hoffmann HM, Nadal R, Vignes M, Ortiz J. Chronic cocaine self-administration modulates ERK1/2 and CREB responses to dopamine receptor agonists in striatal slices. Addict Biol. 2011; 17, 565–575 PMID: 21812869
4. González-Sepúlveda M, Rosell-Villar S*, Hoffmann HM*, Castillo-Ruiz M, Mignon V, Moreno-Delgado M, Vignes M, Díaz J, Sabriá J, Ortiz J. Cellular distribution of the histamine H3 receptor in the basal ganglia: Functional modulation of dopamine and glutamate neurotransmission. Basal Ganglia. 2013 July; 3(2):109-121
5. Witham EA, Meadows JD, Hoffmann HM, Shojaei S, Coss D, Kauffman AS, Mellon PL. Kisspeptin regulates gonadotropin genes via immediate early gene induction in pituitary gonadotropes. Mol Endocrinol. 2013 Aug;27(8):1283-94. PMID: 23770611
6. Moreno E, Moreno D, Navarro G, Hoffmann HM, Fuentes S, Rosell-Vilar S, Gasperini P, Rodriguez-Ruiz M, Medrano M, Mallol J, Cortes A, Casado V, Lluis C, Ferre S, Ortiz J, McCormick P, and Canela E. Cocaine disrupts histamine H3 receptor modulation of dopamine D1 receptor signaling: sigma1-D1-H3 receptor complexes as key targets for reducing cocaine's effects. J Neurosci. 2014 Mar 5;34(10):3545-58. PMID: 24599455
7. Hoffmann HM, Tamrazian A, Xie H, Pérez-Millán MI, Kauffman AS, Mellon PL. Heterozygous Deletion of Ventral Anterior Homeobox (Vax1) Causes Subfertility in Mice. Endocrinology 2014 Oct;155(10):4043-53. PMID:25060364
8. Xie H, Hoffmann HM*, Meadows JD*, Mayo SL, Trang C, Leming SS, Maruggi C, Davis SW, Larder R, Mellon Homeodomain Proteins SIX3 and SIX6 Regulate Gonadotrope-specific Genes During Pituitary Development. Mol Endocrinol. 2015 Jun;29(6):842-55. PMID: 25915183
9. Hoffmann HM, Trang C, Gong P, Kimura I, Pandolfi EC, and Mellon PL. Deletion of Vax1 from Gonadotropin-Releasing Hor­mone (GnRH) Neurons Abolishes GnRH Expression and Leads to Hypogonadism and Infertility. J Neurosci. 2016 Mar 23;36(12):3506-18. PMID: 27013679
10. Hoffmann HM, Crouzin N, Moreno E, Raivio N, Fuentes S, McCormick PJ, Ortiz J and Vignes M. Long-lasting impairment of mGluR₅-activated intracellular pathways in the striatum after withdrawal of cocaine self-administration. Int J Neuropsychopharmacol. 2016 Oct 15. PMID: 27744406
11. Hoffmann HM^#, Gong P, Tamrazian A, and Mellon PL. Transcriptional interaction between cFOS and the homeodomain-binding transcription factor VAX1 on the GnRH promoter controls Gnrh1 expression levels in a GnRH neuron maturation specific manner. Mol Cell Endocrinol. 2017 Sep 7. PMID:28890143
12. Xie H*, Hoffmann HM*, Iyer AK, Brayman MJ, Ngo C, Sunshine MJ, and Mellon PL. Chromatin status and transcription factor binding to gonadotropin promoters in gonadotrope cell lines. Reprod Biol Endocrinol. 2017 Oct 24. PMID:29065928
13. Pandolfi EC, Hoffmann HM, Schoeller EL, Mellon PL. Haploinsufficiency of SIX3 Abolishes Male Reproductive Behavior through Disrupted Olfactory Development, and Impairs Female Fertility through Disrupted GnRH Neuron Migration. Molecular Neurobiology. 2018; 55, 8709-8727. PMID: 29589282
14. Hoffmann HM^#. Determination of reproductive competence by confirming pubertal onset and performing a fertility assay in mice and rats. J Vis Exp. 2018 Oct 13;(140). PMID: 30371660
15. Hoffmann HM^*, Larder R^*, Lee JS, Hu RJ, Trang C, Devries BM, Clark DD, and Mellon PL. Differential CRE expression in Lhrh^cre and Gnrh^cre mouse lines and the impact on fertility deleting the transcription factor Otx2. 2019, 108, 328-342. PMID: 30739114
16. Pandolfi EC, Tonsfeldt KJ, Hoffmann HM, Mellon PL. Deletion of the Homeodomain Protein Six6 from GnRH Neurons Decreases GnRH Gene Expression Resulting in Infertility. 2019. 160, 2151-2164. PMID:31211355.

• Featured article in Endocrinology (June 27, 2019)

17. Pandolfi EC, Breuer JA, Huu Van, Talluri T, Nguyen, D, Lee JS, Hu R, Bharti K, Skowronska-Krawczyk D, Gorman MR, Mellon PL, Hoffmann HM^#. The Homeodomain Transcription Factors Vax1 and Six6 are Required for SCN Development and Function. Molecular Neurobiology. 2019 Nov 9. PMID: 31705443
18. Yaw AM*, Duong T*, Nguyen D, and Hoffmann HM^#. Circadian rhythms in the mouse reproductive axis during the estrous cycle and pregnancy. J Neurosci Res. 2020 Mar 3. PMID: 32128870
19. Coré N, Erni A, Hoffmann HM, Mellon PL, Saurin AJ, Béclin C, Cremer H. Stem cell regionalization during olfactory bulb neurogenesis depends on regulatory interactions between Vax1 and Pax6. 2020 Aug. PMID: 32762844
20. Lavalle SN, Chou T, Hernandez J, Naing NCP, Tonsfeldt KJ, Hoffmann HM, Mellon PL. Kiss1 is Differentially Regulated in Male and Female Mice by the Homeodomain Transcription Factor VAX1. Molecular Cellular Endocrinology 2021534(8), 111358. PMID: 34098016. PMC8319105.
21. Hoffmann HM*^#, Meadows JD*, Breuer JA, Devries BM, Yaw AM, Oosterhouse HJ, Chen A, Trang C, Sora JL, Doser JW, Gorman MR, Welsh DK, Mellon PL. The transcription factors SIX3 and VAX1 are required for suprachiasmatic nucleus circadian output and fertility in female mice. J Neurosci Res. 2021 July 2. PMID: 4212416
22. Zhou G^#, Duong TV, Kasten EP, Hoffmann HM^#. Low CLOCK and CRY2 in 2nd Trimester Human Maternal Blood and Risk of Preterm Birth: a Nested Case-Control Study. Biol Reprod. 2021 Jun 18. PMID: 34142702. PMCID: PMC8511660
23. Meadows JD, Breuer JA, Lavalle SN, Hirschenberger MR, Meera M. Patel, Nguyen D, Kim A, Jessica Cassin, Gorman MR, Welsh DK, Mellon PL, Hoffmann HM^#. Deletion of Six3 in post-proliferative neurons produces weakened SCN circadian output, improved metabolic function, and dwarfism in male mice. Mol Metab. 2021 Dec 31;57:101431. PMID: 34974160
24. Sambit Roy*, Aierken Abudu*, Irving Salinas, Niharika Sinha, Holly Cline-Fedewa, Alexandra M. Yaw, Wenjie Qi, Todd A. Lydic, Diana L. Takahashi, Jon D. Hennebold, Hanne M. Hoffmann, Jianrong Wang, and Aritro Sen. Androgen-mediated perturbation of the hepatic circadian system through epigenetic modulation promotes NAFLD in PCOS mice. 2022 Oct 1;163(10):bqac127. PMID: 35933634
    • Featured article in Endocrinology (October 6, 2022)
25. Guoli Zhou, Emily Winn, Eric P. Kasten, Margaret G. Petroff, Hanne M. Hoffmann^#. Co-Alterations of Circadian Clock Gene Transcripts in Human Placenta in Preeclampsia. Sci Rep. 2022 Oct 25;12(1):17856. PMID: 36284122
26. Mike R. Wilson, Hilary Skalski, Jake J. Reske, Marc Wegener, Marie Adams, Galen Hostetter, Hanne M. Hoffmann, Jamie J. Bernard, Victoria L. Bae-Jump, Jose M. Teixeira and Ronald L. Chandler. Obesity alters the endometrial transcriptome in a cell context-dependent manner. Reprod Biol Endocrinol. 2022 Nov 24;20(1):163. PMID: 36424602
27. Guoli Zhou, Raina N. Fichorova, Claudia Holzman, Bin Chen, Chi Chang, Eric P. Kasten, Hanne M. Hoffmann#. Placental circadian lincRNAs and spontaneous preterm birth. Front Genet. 2023 Jan 11. PMID: 36712876
28. Devries BM^*, Yaw AM^*, Breuer JA, Jackson B, Nguyen D, Tonsfeldt K, Ho EV, Cui L, Gorman MR, Sempere L, Mellon PL Hoffmann HM^#. The transcription factor Ventral Anterior Homeobox 1 regulates circadian time-keeping through a direct transcriptional regulation of the clock genes Bmal1 and Per2 in VIP neurons of the suprachiasmatic nucleus [in preparation]

* Authors contributed equally to the work

# Corresponding author

reviews, book chapters AND PERSPECTIVES

1. Hoffmann HM^# and Mellon PL. A small population of neurons govern fertility: the critical role of VAX1 in GnRH neuron development and fertility maintenance. Invited research highlight for Neuroscience Communications. Neurosci Commun (Houst). 2016;2. pii: e1373. PMID: 28164172
2. Hoffmann HM and Mellon PL. Regulation of GnRH gene expression. Book chapter in The GnRH neuron and its Control edited by Allan Herbison and Tony Plant. John Wiley & Sons. Feb 19, 2018
3. Hoffmann HM^*, Larder R^*, Pandolfi EC^*, Mellon PL. Haploinsufficiency of Homeodomain Proteins Six3, Vax1, and Otx2, Causes Subfertility in Mice Via Distinct Mechanisms. Neuroendocrinology. 2019;109(3):200-207. PMID: 30261489
4. Sen A, Hoffmann HM^#. Role of core circadian clock genes in hormone release and target tissue sensitivity in the reproductive axis. Molecular and Cellular Endocrinology. 2020; 5;501:110655. PMID: 31756424
5. Kauffman AS, Hoffmann HM^#. Editorial: Hormone release patterns in mammals. Mol Cell Endocrinol. 2020 Feb 28:110781. PMID:32119896
6. Yaw AM, McLane-Svoboda AK and Hoffmann HM^#. Shiftwork and light-at-night negatively impact molecular and endocrine timekeeping in the female reproductive axis in humans and rodents. Int. J. Mol. Sci. 2021, 22(1), 324; PMID:33396885. PubMed Central PMCID: PMC7795361.
7. Tonsfeldt K, Mellon PL, Hoffmann HM^#. Circadian rhythms in the neuronal network timing the LH surge. Endocrinology. 2022 Feb 1. PMID: 34967900
8. Yaw AM, Devries BM, Hoffmann HM. Disrupted Circadian Rhythms and Neuroendocrine Function [In press. Invited book chapter for “Biological Implications of Circadian Disruption: A Modern Health Challenge” Edited by: Laura K. Fonken and Randy J. Nelson]
9. Hoffmann HM. Boosting cognition with a hormone. Perspective. Science. 2022, Vol. 377, No 661. DOI: 10.1126/science.add9456

* Authors contributed equally to the work

# Corresponding author

INTERVIEWS and in the news

1.     AAAS Eureka awards. Feb 1, 2017. Endocrine Society honors Early Investigators Award winners. https://www.eurekalert.org/pub_releases/2017-02/tes-esh013117.php

2.     News wise Feb 1, 2017. Endocrine Society Honors Early Investigators Award Winners https://www.newswise.com/articles/endocrine-society-honors-early-investigators-award-winners?sc=rsla

3. Interview “Two minutes with: Hanne Hoffmann on new techniques for behavior”, BioTechniques, Nov 23, 2018. https://www.biotechniques.com/omics/two-minutes-with-hanne-hoffmann-on-new-techniques-for-behavior/
4. Interviewed to comment on “This Small Norwegian Island, Where The Sun Doesn’t Set For 69 Days, Wants To Abolish Time” written by Natasha Ishak. June 20, 2019. https://allthatsinteresting.com/sommaroy-island-abolish-time
5. Interviewed for Life Style article in Yahoo, entitled “Seasonal affective disorder: Why some feel sluggish and sad during winter time”. Nov 4, 2019. https://www.yahoo.com/lifestyle/what-is-seasonal-affective-disorder-232326359.html
6. Interviewed for Healthline.com article, entitled “Daylight Saving Time: ‘Falling Back’ Can Increase Seasonal Depression”. Nov 7, 2019. https://www.healthline.com/health-news/daylight-saving-time-and-seasonal-depression
7. Interviewed by Prevention.com for the article “How to Cope With Seasonal Depression During the COVID-19 Pandemic, Lift your mood with these expert-approved tips”. Nov 16, 2020. https://www.prevention.com/health/mental-health/a34588431/seasonal-affective-disorder-covid-19-pandemic/ and https://www.prevention.com/health/mental-health/a30244835/seasonal-affective-disorder-symptoms/. Following interviewed on 2021 and 2022 for an updated version of the article.
8. Video interview on seasonal depression and how to prevent it posted on Nov 17, 2020 at NewsPoint360, a recent YouTube channel with the goal to inform the public on diverse topics through evidence-based perspectives of experts. https://np360media.net/HanneHoffmann
9. Interviewed by MSU today on Nov 18, 2020 for the Ask the expert series on “Light, seasonal affective disorder and COVID-19”. https://msutoday.msu.edu/news/2020/ask-the-expert-light-seasonal-affective-disorder-and-covid-19
10. Interview by Huffington Post on Nov 20, 2020 entitled “Light Therapy Lamps: What’s The Difference Between Cheap and Expensive Ones?”. https://www.huffpost.com/entry/light-therapy-lamps-difference-cheap-expensive_l_5fb682c4c5b664958c7e48d1
11. Interview by Health on Dec 1, 2020 entitled “Will Seasonal Affective Disorder Be Worse This Year Because of COVID-19?”. https://www.health.com/condition/depression/seasonal-affective-disorder-covid-19
12. Interviewed by the College of Agriculture and Natural Resources (CANR) at MSU, March 1, 2021 entitled “MSU seeking solutions for preterm birth”. https://www.canr.msu.edu/news/msu-seeking-solutions-for-pre-term-birth
13. Live Radio interview for 630 CHED in Edmonton on March 15, 2021, on the topic of the Impact of Daylight Saving Time and Seasonal Depression on People. Interviewed by Chelsea Bird.
14. Interviewed by Jillian Crocetta for the Magazine Sanctuary in March 2021, on the topic of “The Benefits of Light Therapy for Those who Suffer from Seasonal Affective Disorder”. https://www.sanctuary-magazine.com/alternative-therapy.html
15. Interviewed by Korin Miller for VeryWell on June 4, 2021, on the topic of “You can get SAD in the summer too”. https://www.verywellhealth.com/summer-seasonal-affective-disorder-5187898
16. Our published work aimed at discovering biomarkers allowing to identify mothers at risk of preterm birth was featured in MSU today. July 29, 2021. https://msutoday.msu.edu/news/2021/identifying-mothers-at-risk-of-preterm-births
17. Interviewed by Amber Pardilla from the NY magazine, The Strategist ,for “The Best SAD Lamps, According to Experts” on Sep 16, 2021 and an updated version by Lizza Corsillo on Nov 3, 2022.  https://nymag.com/strategist/article/best-sad-lamps.html.  
18. Interviewed by Alexey Gorbachev from Voice of America (VOA) on our preterm birth research. The resulting TV package, based on interviews with numerous scientists, was released in September 2021 as part of the VOA Russian broadcast. It was also broadcasted by Current Time TV. Current Time is produced by Radio Free Europe/Radio Liberty (RFE/RL) in cooperation with the Voice of America (VOA), which airs on more than 30 media outlets globally and has drawn more than 100 million video views. https://www.golosameriki.com/a/detali/6222379.html and https://www.currenttime.tv/a/31455634.html
19. Commented on a new study published in Science on the capacity of GnRH to boost cognition published on Sep. 2, 2022. Interviewed by Dennis Thompson at HealthDay (https://consumer.healthday.com/9-1-emb-2pm-in-small-study-hormone-boosts-thinking-skills-in-men-with-down-syndrome-2657957518.html), Simon Making for Scientific American (https://www.scientificamerican.com/article/a-hormone-may-boost-cognition-in-down-syndrome/) and by Migel Angleo Criado at El Pais (major Spanish newspaper, https://elpais.com/ciencia/2022-09-01/una-terapia-experimental-mejora-las-habilidades-cognitivas-de-personas-con-sindrome-de-down.html)
20. Interviewed by Jenna Malinowski at State News for a story entitled “Why Michigan State will sleep no longer than 30 minutes on trip to Washington” published on Sep. 15, 2022 . https://statenews.com/article/2022/09/why-michigan-state-will-sleep-no-longer-than-30-minutes-on-trip-to-washington
21. Interviewed by Jack Armstrong at State News for a story entitled “MSU professors discuss ways to increase sleep quality, why you might be so tired” published on Sep 21, 2022. https://statenews.com/article/2022/09/msu-professors-discuss-ways-to-increase-sleep-quality-why-you-might-be-so-tired
22. Interviewed by Loren Cecil for buzz feed news for a story entitled “Light Therapy Lamps To Try If You Find Dark Days Depressing”, published on October 24, 2022. https://www.buzzfeednews.com/article/lorencecil1/sad-light-therapy-lamp
23. Interviewed by Matt Gonzales for the Society for Human Resource Management(SHRM) on “The Winter Blues: How Less Sunlight Influences Workplace Productivity” on 16, 2022. https://www.shrm.org/resourcesandtools/hr-topics/behavioral-competencies/global-and-cultural-effectiveness/pages/the-winter-blues-how-less-sunlight-influences-workplace-productivity.aspx
24. Radio interview by Kevin Lavery at KWAR on seasonal depression and how to prevent it. Aired numerous times in late December 2022.
25. Interviewed by Kelly House from Bridge Michigan for an article entitled “Michigan winters are super cloudy and getting worse. Here’s how to deal” published on Jan.9, https://www.bridgemi.com/michigan-environment-watch/michigan-winters-are-super-cloudy-and-getting-worse-heres-how-deal
26. Radio interview by Heather Bricca from Up North Live on seasonal depression and how to prevent it. Aired in January 2023

Oral communicationS

2010     Hanne M. Hoffmann, Michel Vignes, Jordi Ortiz. Crosstalk of histamine H3 receptors and metabotropic glutamate 5 receptors regulates synaptic transmission in the brain. Simposi de neurobiologia experimental, Societat Catalana de Biologia (October 2010, Barcelona, Spain).

2014     Hanne M. Hoffmann, Anika Tamrazian, Pamela L. Mellon. Vax1 heterozygous mice exhibit male and female subfertility: Central versus peripheral origins. Poster Preview Presentation at ICE/ENDO 2014 (Endocrine Society), Chicago, IL (June 2014, USA).

• Selected for the Presidential Poster Competition
• Recipient of the Early Career Forum Travel award by Women in Endocrinology

2015     Hanne M. Hoffmann, Ikuo Kimura, Ping Gong, Crystal Trang, Alexander S. Kauffman, Pamela L. Mellon. Absence of Vax1 in GnRH neurons abolishes GnRH expression and leads to hypogonadism: Investigating the role of the homeoprotein, Vax1, in GnRH neuron maturation. ENDO 2015 (Endocrine Society), San Diego, CA (March 2015). 

• Recipient of 2015 Endocrine Society Outstanding Abstract Award

2016     Hanne M. Hoffmann, Jason D. Meadows, Crystal Trang, Brittainy Hereford, Kapil Bharti, Michael R. Gorman, Pamela L. Mellon. Deletion of SIX3 or VAX1 in the SCN impairs circadian rhythms and fertility. ENDO 2016 (Endocrine Society), Boston, MA (March 2016).

• Recipient of the 2016 Neena Schwartz Young Investigator Award in Basic Science
• Recipient of the 2016 Early Investigators Award supported by Merck & Co., Inc.

2017     Hanne M. Hoffmann, Jessica S. Lee, Jason D. Meadows, Crystal Trang, Haley J. Oosterhouse, Erica C. Pandolfi, Michael R. Gorman, David K. Welsh, Pamela L. Mellon. Circadian and neuroendocrine control of reproduction. Society for Behavioral Neuroendocrinology (Long Beach, CA, June 2017)

• Recipient of the 2017 New Investigator Award from the Society for Behavioral Neuroendocrinology

2018     Hanne M. Hoffmann, Erica C. Pandolfi, Jessica S. Lee, Rachael J. Hu, Crystal Trang, Viet A. Nguyen, Dorota Skowronska-Krawczyk, Michael R. Gorman, Pamela L. Mellon. The importance of characterizing Cre-alleles: a comparative study of the impact of neuronal development and behavior in mice with conditional deletion of the homeodomain transcription factors Six6 and Vax1 using two different Gnrh-promoter driven Cre-alleles. Society for Neuroscience (SFN, San Diego, CA, November 2018)

2021     Hanne M Hoffmann. The Role of Circadian Clocks in Reproduction. Symposium: Advances in Understanding the GnRH Pulse Generator (ENDO2021. March 2021. Virtual event)

2021     Hanne M Hoffmann. Dual receptor targeting as a novel strategy to improve labor-regulating drug efficacy. The American Society for Reproductive Immunology (ASRI, May 2021. Virtual event)

Invited TALKS

2014     Rhythms, hormones and fertility. CCB Fall Workshop on Biological Timing, San Diego, CA (November 2014).

2016     School of Medicine and Dentistry, University of Rochester Medical Center, Rochester, NY (August 2016).

2016     Reproductive Endocrinology Unit of the Department of Medicine, Harvard Medical School, Mass. General Hospital. Boston, MA (March 2016).

2016     Reproductive Medicine Retreat. School of Medicine, UC San Diego, CA (September 2016).

2017     Department of Biochemistry and Molecular Genetics, University of Louisville School of Medicine, Louisville, KY (January 2017).

2017     Department of Comparative Biosciences, College of Veterinarian Medicine, University of Urbana-Champaign, Urbana-Champaign, IL (February 2017).

2017     College of Engineering, Forestry and Natural Sciences, Northern Arizona University, Flagstaff, AZ (February 2017).

2017     School of Biological Sciences, Georgia Institute of Technology, Atlanta, GA (February 2017).

2017     Department of Animal Science, Michigan State University, East Lansing, MI (March 2017).

2017     Department of Molecular, Cellular and Biomedical Sciences, New Hampshire University, Durham, NH (April 2017).

2017     Department of Biological Sciences, Kent State University, Kent, OH (May 2017).

2017     Department of Physiology and Biophysics, University of Illinois, Chicago, Chicago, IL (August 2018).

2018     Circadian and Neuroendocrine Control of Reproduction. The 9^th annual Michigan Alliance for Reproductive Technologies and Science (MARTS). Grand Rapids, MI (May 2018).

2019     Department of Biomedical Engineering, Tulane School of Medicine. New Orleans, LA (March 2019).

2019     Translational Science Seminar Series. Michigan State University, Grand Rapids, MI (October 2019).

2019     Mott Center For Human Growth and Development Seminar Series. Wayne State University, MI (December 2019).

2020     ENDURE Program (National Institute of Environmental Health Sciences, R25) seminar for undergraduate minorities. Michigan State University, East Lansing, MI (November 2020)

2021     Reproductive and Developmental Science Program (RDSP) program seminar. Michigan State University, East Lansing, MI (June 2021)

2021     Interdisciplinary Reproduction and Health Group (IRHG) seminar series.  University of Missouri, Missouri (December 2021)

2021     Biological Rhythms and Sleep (BRS) seminar series. University of Michigan, Michigan (December 2021)

2022     Pathology seminar series, University of Illinois Chicago, Chicago, Illinois (April 2022)

2022     Low CLOCK and CRY2 in 2nd Trimester Human Maternal Blood and Risk of Preterm Birth a Nested Case Control Study. The BOR Winners Webinar Series. (Sep. 21, 2022, Virtual event).

Posters

1. Valerie Compan, Hanne M. Hoffmann, V Mendizabal, Alexandra Jean, Gregory Conductier, Letitia Laurent, P. Berta, Rafael Maldonado, Joel Bockaert. Deletion of the serotonin 4 receptors differentially affects cocaine-induced anorexia, locomotor activity and CREB phosphorylation in the nucleus accumbens. 8th Colloque Montpellier (May 2007 France)
2. Hanne M. Hoffmann, Michel Vignes, Jordi Ortiz. Chronic cocaine self-administration alters ERK1/2 and CREB responses to dopamine receptor agonists. Society for Neuroscience 2010 (November 2010, San Diego USA)
3. Hanne M. Hoffmann, Ping Gong, Pamela L. Mellon. Involvement of cFos in ventral anterior homeobox 1 regulation of gonadotropin-releasing hormone transcription in maturing gonadotropin-releasing hormone neurons. Society for Neuroscience 2012, New Orleans (October 2012, USA)
4. Hanne M. Hoffmann, Ikuo Kimura, Ping Gong, Anika Tamrazian, Alexander S. Kauffman, Pamela L. Mellon. Vax1 is required for generation of hypothalamic GnRH Neurons, GnRH Gene Expression, and normal reproductive function in mice. Society for Neuroscience 2013, San Diego (November 2013, USA)
5. Erica C. Pandolfi, Hanne M. Hoffmann, Jason D. Meadows, Pamela L. Mellon. The Homeodomain Protein, Six3 is Important in the Development of GnRH Neurons in Mice. ICE/ENDO 2014 (Endocrine Society), Chicago, IL (June 2014, USA)
6. Hanne M. Hoffmann, Anika Tamrazian, Pamela L. Mellon. Vax1 heterozygous mice exhibit male and female subfertility: Central versus peripheral origins. ICE/ENDO 2014 (Endocrine Society), Chicago, IL (June 2014, USA)
7. Hanne M. Hoffmann, Jason D. Meadows, Crystal Trang, Brittainy Hereford, Haley Oosterhouse, Kapil Bharti, Michael R. Gorman, Pamela L. Mellon. Deletion of SIX3 or VAX1 in the SCN impairs circadian rhythms and fertility. CCB symposium: From Cells to Clinic, Center for Circadian Rhythms, San Diego (February 2016)
8. Erica C. Pandolfi, Hanne H. Hoffmann, Erica L. Schoeller, Pamela L. Mellon. The Homeodomain Gene Six3 Is important in GnRH Neuron Migration and Olfaction in Mice. Society for the Study of Reproduction, San Diego (July 2016, USA)
9. Erica C. Pandolfi, Hanne M. Hoffmann, Erica L Schoeller, Pamela L Mellon. (2016). Haploinsufficiency of the homeodomain protein Six3 abolishes male reproductive behavior through disrupted olfactory epithelium development and impaired GnRH neuron migration. The Society for Neuroscience Annual Meeting. San Diego (November 2016, USA)
10. Hanne M. Hoffmann, Crystal Trang, Brittainy Hereford, Kapil Bharti, Michael R. Gorman, David K. Welsh, Pamela L. Mellon. Ventral Anterior Homeobox 1 is Required for Suprachiasmatic Nucleus Development as well as Circadian Output in Adulthood Allowing Female Fertility. The Society for Neuroscience Annual Meeting, San Diego (November 2016, USA).
11. Erica C. Pandolfi, Hanne M. Hoffmann, Erica L. Schoeller, Pamela L. Mellon. The Importance of Six3 and Six6 Homeodomain Genes in GnRH Neuron Development, Olfaction, and Fertility. Society for the Study of Reproduction (July 2017, Washington DC, USA).
    • Oral presentation Erica C. Pandolfi
12. Hanne M. Hoffmann, Joseph A. Breuer, Jessica S. Lee, Jason D. Meadows, Michael R. Gorman, David K. Welsh, and Pamela L. Mellon. Females Require Circadian Alignment of Reproductive Tissues to Maintain Fertility. 12^th Annual Salk Institute, Foundation IPSEN and Science Symposium on Biological Complexity. (January 2018, La Jolla, CA).
13. Hanne M. Hoffmann, Erica C. Pandolfi, Rachel Larder, Jessica S. Lee, Rachael J. Hu, Crystal Trang, Daniel D. Clark, Michael R. Gorman, Pamela L. Mellon. Significant differences in fertility and circadian behavior due to deletion of the homeodomain transcription factors Six6, Vax1, or Otx2 using two different GnRH-cre mouse lines. ENDO 2018 (March 2018, Chicago, IL).
    • Selected for presidential poster competition (declined).
14. Pamela L. Mellon, Erica C. Pandolfi, Hanne M. Hoffmann. The Roles of Homeodomain Proteins in GnRH Neuronal Development and Fertility. Neuroendocrinology-International Congress of Neuroendocrinology (July 2018, Toronto, Canada).
    • Invited speaker Pamela L. Mellon
15. Hanne M. Hoffmann, Joseph A. Breuer, Jessica S. Lee, Jason D. Meadows, Michael R. Gorman, David K. Welsh, Pamela L. Mellon. Circadian rhythm synchrony is required for estrous cycling and female fertility. Neuroendocrinology-International Congress of Neuroendocrinology (July 2018, Toronto, Canada).
16. Thu Duong, Duong Nguyen, Hanne M. Hoffmann. Elucidating the role of the circadian clock gene Bmal in myometrium function during pregnancy. Reproductive and Developmental Science Program Research Retreat, MSU (November 2018, Portland, MI)
17. Thu Duong, Duong Nguyen, Hanne M Hoffmann. Circadian rhythms of the uterine myometrium are involved in its daily changes in sensitivity to the labor promoting hormone oxytocin. 11th Annual Graduate Academic Conference, 16th February 2019 at the MSU Union in East Lansing, MI
    • Oral presentation by Thu Duong
18. Aierken Abudu, Sambit Roy, Olivia Nave, Jie Wang, Kevin Childs, Michael T. Sellix, Hanne M. Hoffmann, Aritro Sen. Androgen-Induced Disruption of the Biological Clock: The Link between PCOS and NAFLD. ENDO 2019 (March 2019, New Orleans, LA). Journal of the Endocrine Society, Volume 3, Issue Supplement_1, April-May 2019, MON-230, https://doi.org/10.1210/js.2019-MON-230
    • Outstanding poster award
19. Thu Duong, Duong Nguyen, Hanne M. Hoffmann. Elucidating the role of the circadian clock gene Bmal in myometrium function during pregnancy. AAP/ASCI/APSA joint meeting 2019 (April 2019, Chicago, IL)
20. Thu Duong, Hanne M. Hoffmann. Time-of-day impacts uterine contractility and drug efficacy. 14.th Annual Animal Science Graduate Research Forum. Michigan State University (October 2019).
    • Oral presentation by Thu Duong
21. Hanne M. Hoffmann, Thu V Duong, Duong Nguyen, Asad Muhammed, Alexandra M Yaw. Pregnancy Adapts Circadian Rhythms in the Reproductive Axis: Impact on Labor Regulating Drug Efficacy. ENDO 2020 (March 2020, San Francisco, CA). Conference canceled due to COVID-19. Journal of the Endocrine Society, Volume 4, Issue Supplement_1, April-May 2020, MON-015, https://doi.org/10.1210/jendso/bvaa046.376
22. Brooke M. Devries, Joseph A. Breuer, Alexandra M. Yaw, Brooke Jackson, Duong Nguyen, Emily V. Ho, Tulasi Talluri, Laura Cui, Michael R. Gorman, Lorenzo F Sempere, Pamela L. Mellon, Hanne M. Hoffmann. The Transcription Factor Ventral Anterior Homeobox 1 Modulates Circadian Time-Keeping and Fertility Through Direct Regulation of Vasoactive Intestinal Polypeptide Expression in the Suprachiasmatic Nucleus. ENDO 2021 (March 2021, virtual event due to COVID-19). Journal of the Endocrine Society, Volume 5, Issue Supplement_1, April-May 2021, Page A556, https://doi.org/10.1210/jendso/bvab048.1134
    • Outstanding poster award to Brooke Devries
23. Thu Duong, Alexandra Yaw, Duong Nguyen, Hanne M. Hoffmann. The circadian clock gene Bmal1 modulates myometrium contractile function in pregnant mice. ENDO 2021 (March 2021, virtual event due to COVID-19). Journal of the Endocrine Society, Volume 5, Issue Supplement_1, April-May 2021, Pages A754–A755, https://doi.org/10.1210/jendso/bvab048.1534
    • Outstanding poster award to Thu Duong
24. Alexandra M. Yaw, Autumn Mclane-Svoboda, Duong Nguyen, Thu Duong, and Hanne M. Hoffmann. A mouse model of shiftwork reveals sex-specific impairments in circadian behavior and reproductive tissue timekeeping. ENDO 2021 (March 2021, virtual event due to COVID-19). Journal of the Endocrine Society, Volume 5, Issue Supplement_1, April-May 2021, Pages A530–A531, https://doi.org/10.1210/jendso/bvab048.1080
25. Alexandra M. Yaw, Autumn K. Mclane-Svoboda, Duong Nguyen, Krystal Jang, and Hanne M. Hoffmann. Location, location, location: Facility site-and sex-specific impairments in mouse circadian timekeeping and fertility in response to rotating light shifts. 11^th Annual Michigan Alliance for Reproductive Technologies and Sciences (MARTS). University of Michigan, Ann Arbor, MI (October 7 and 8, 2021, virtual event)
26. Thu Duong and Hanne Hoffmann. The circadian clock gene Bmal1 modulates myometrium contractile function in pregnant mice. 11^th Annual Michigan Alliance for Reproductive Technologies and Sciences (MARTS). University of Michigan, Ann Arbor, MI (October 7 and 8, 2021, virtual event)
    • 1^st Keith Inskeep Best Poster Presentation Award Winner (awarded to Thu Duong)
27. Aneesh S. Cherukuri, Thu Duong, Hanne M. Hoffmann. Promising novel drug targets to halt preterm labor through dual targeting of oxytocin and melatonin receptors. 11^th Annual Michigan Alliance for Reproductive Technologies and Sciences (MARTS). University of Michigan, Ann Arbor, MI (October 7 and 8, 2021, virtual event)
28. Hanne M. Hoffmann, Thu Duong, Duong Nguyen, Wen Li. The Molecular Clock is a Novel Pharmacological Target to Regulate Uterine Contractions in Pregnancy. Society for Research on Biological Rhythms 2022. Amelia Island, Florida (May 14-18, 2022)
    • Selected for data flash presentation
29. Hanne M. Hoffmann, Jacquelyn Jacobs, Mary E. Gardella, Grace Jaksen, Jessica Crane, Kathryn Hurt, Skylar Mack, Eleanor Vondette, Alexandra M. Yaw. Light Composition Alters Feline Stress and Behavior in a Shelter Environment. Society for Research on Biological Rhythms 2022. Amelia Island, Florida (May 14-18, 2022)
30. Brooke M. Devries, Alexandra M. Yaw, Brooke Jackson, Fabiola Ramos, Michael Gorman, Lorenzo Sempere, Pamela Mellon, Hanne M. Hoffmann. Weakened VIP neuron function in female mice is associated with reduced FSH and estrogen and lengthened estrous cycles. 12^th Annual Michigan Alliance for Reproductive Technologies and Sciences (MARTS). Wayne State University, Detroit, MI (September 16, 2022)
31. Alexandra M. Yaw, Brooke M. Devries, Autumn K. Mclane-Svoboda, Duong Nguyen, Krystal Jang, and Hanne M. Hoffmann. Dichotomic effect of chronic rotating light shifts on female neuroendocrine control of the reproductive axis in mice. 12^th Annual Michigan Alliance for Reproductive Technologies and Sciences (MARTS). Wayne State University, Detroit, MI (September 16, 2022)
32. Rachel Eck, Thu Duong, Hanne M. Hoffmann. Oxytocin and Melatonin in Defining Uterine Contractions in Pregnancy. 12^th Annual Michigan Alliance for Reproductive Technologies and Sciences (MARTS). Wayne State University, Detroit, MI (September 16, 2022)

PANELIST

2014     UCSD career seminar, “Learn at Lunch: Alumni Career Panel Women in Science (STEM)” at the UC San Diego’s Career Services Center. February 4, 2014.

2015     UCSD postdoc Health and Wellness series, “Working Postdoc with Small Children: How to Effectively Manage Your Two Jobs”. April 15, 2015.

2016     Panelist at the Center for Circadian Biology (CCB) Fall Workshop on Biological Timing. Professional Development Panel – Career advice and strategies for trainees. UC San Diego. November 11, 2016

2017     Panelist at the UCSD Postdoc Association “STEM Academic Job Search Panel”. UC San Diego. October 3, 2017.

2017     Panelist at the Center for Circadian Biology (CCB) Fall Workshop on Biological Timing. Professional Development Panel – F/K award grant tips. UC San Diego. November 17, 2017.

TEACHING

2016                 Guest lecturer in the graduate Biology program at California State University, Fresno. Title: Deletion of the transcription factor Vax1 affects neuronal development and impairs fertility. Fresno, CA (May 2016).

2016                 Assisting instructor in the graduate course NEU221 Advanced Topics in Neurosciences. UC San Diego (Fall 2016).

2018                 Guest lecturer in the graduate Neuroscience program at Michigan State University. Title: Circadian Control of Neuroendocrine Rhythms and Reproduction. MSU, East Lansing, MI (October 2018).

2018-2021        Co-instructor in undergraduate course ANS 409 “Problems, Controversies and Advancements in Reproduction”. MSU, East Lansing, MI.

2020-current     Guest lecture on stress in welfare in undergraduate course ANS 200E “Introductory Animal Welfare Assessment”. MSU, East Lansing, MI.

2021-2022        Lead instructor in undergraduate course ANS 490-470 “Stress and its role in behavior and wellbeing”. MSU, East Lansing, MI.

03/2021            Guest lecture (1 session) in graduate course NEU 233 “Circadian Rhythms and Health”. UC San Diego. CA.

2021-current     Guest lecture (1 or 2 sessions in Spring and Fall semester) on the reproductive axis and reproductive behaviors in undergraduate course ANS 210 “Animal Products”. MSU, East Lansing, MI.

2021-current     Guest lecture (1 session) on seasonality in undergraduate course ANS 315 “Anatomy and Physiology of Farm Animals”. MSU, East Lansing, MI.04/

04/2022            Guest lecture (1 sessions) on pregnancy DO OSTP597. MSU, East Lansing, MI

2022-current.     Guest lecture (1 session) on female sexual behavior in graduate course NEU802 “Behavioral Neuroscience”. MSU, East Lansing, MI.

2023-current     Lead instructor in undergraduate course ANS 411 “Neuroendocrine control of stress and physiology”. MSU, East Lansing, MI.

OUTREACH AND COMMITTEES 

2012-2016        Committee member of the Strategy Session, AWIS San Diego, CA.

2013-2015        Co-chair of the Strategy Session, AWIS San Diego.

2014-2018        Co-founder and member of the Circadian Trainees 7 (CT7) committee at the Center for Circadian Biology at UC San Diego.

2015-2020        Committee member of the Mentoring Committee at Women in Endocrinology.

2019-2020        Chair of the Reproductive and Developmental Science Program Seminar Series, MSU.

2019-2022        Committee member of the Department Advisory Committee, Department of Animal Science, MSU.

2020-2022        Program committee for the International Congress of Neuroendocrinology 2022. Leader of the “Behavior” program sub-committee.

2020-current     Committee member of the Faculty Advisory Committee (2020-2022), committee changed name to Neuroscience Executive Committee (2022-2023).  Neuroscience Program, MSU.

2022-current     Committee member of the Interdisciplinary Science and Technology Building Governance Committee, MSU.

REVEIWER 

2010-                Peer reviewer for: Biology of Reproduction, Experimental Physiology, European Journal of Cell Biology, Frontiers in Neuroendocrinology, International Journal of Environmental Research and Public Health, International Journal of Molecular Sciences, Human Reproduction, Molecular and Cellular Endocrinology, Neuroendocrinology, Molecules, Molecular Reproduction and Development, Photochemical & Photobiological Sciences, PLOS ONE, Reproduction, Science, Nature.

2020-                Endocrine society yearly meeting (ENDO) abstract reviewer.

2020-2022        Strategic Partnership Grant (SPG) review panel on Basic and Applied Biology (MSU).

2021                 NIH  Early Career Reviewer on the Behavioral Neuroendocrinology, Neuroimmunology, Rhythms and Sleep (BNRS) Study Section.

2021                 Michigan-Alliance for Animal Agriculture (M-AAA) grant reviewer (MSU).

Service AND OUTREACH

• Expanding your horizon Univ. San Diego, presenting “The Chemistry of Beauty” designed for a 7-9^th grade audience (2012)
• Volunteering at the UCSD outreach program “Society for Undergraduate Research and Outreach” (SURO, 2014-2018)
• Mentor in the Mentor Assistance Program (MAP) at UC San Diego (2015-2016)
• Associate Faculty of Faculty of 1000 (2016-2019)
• Moderator of oral session entitled “Enriching Human Life and Society I” (Graduate Student and Postdocs), at the UC San Diego Frontiers of Innovation Scholars Program (FISP) Symposium, UC San Diego (October 31, 2017)
• Editorial board of Molecular and Cellular Endocrinology (2018-current)
• Chair of symposium “Circadian and seasonal changes in brain function and behavior”, at the Society for Behavioral Neuroendocrinology-International Congress of Neuroendocrinology. Toronto Canada (SBN/ICN, July 2018)
• Judge: Three Minute Thesis Competition sponsored by the Endocrine Society at the Society for Behavioral Neuroendocrinology-International Congress of Neuroendocrinology. Toronto Canada (SBN/ICN, July 2018)
• Chair of nanosymposium: "Advances in Molecular, Genetic, and Imaging Techniques". Neuroscience 2018 San Diego, CA (SFN 2018)
• Judge at the 10th Annual Animal Science Undergraduate Research Forum (ASURF) at Michigan State University (April 12, 2019)
• Poster judge at the Symposium on the Neurobiology of Motivated Behavior, Michigan State University (May 16, 2019)
• Organizer of 10^th Annual Michigan Alliance for Reproductive Technologies and Sciences (MARTS). Michigan State University, East Lansing, MI (May 31, 2019)
• Poster judge at the Annual Research Day for the Reproductive and Developmental Science Program (MSU). Portland, MI (Sep 26, 2019)
• Session moderator. 11^th Annual Center for Circadian Biology Symposium, UC San Diego, “From Cells to Clinic”. Special Themes: Circadian Medicine, Microbiome, Metabolism. (Virtual, Feb 9-11, 2021)
• Mentor in the MSU Biomolecular Science (BMS) mentorship program aimed improve the BMS graduate programs efforts to recruit and retain young scientist from under-represented backgrounds (August 2021-current)
• Poster and oral presentation judge at the 11^th Annual Michigan Alliance for Reproductive Technologies and Sciences (MARTS). University of Michigan, Ann Arbor, MI (October 7 and 8, 2021, virtual event)
• Judge at the 2022 Annual Animal Science Graduate Research Forum (ASGRF) at Michigan State University (October 20, 2022)

STUDENTS MENTORED

Michigan State University (2018-current)

Postdoctoral Scholars

1. Alexandra Yaw. PhD from Kent State University. (June 17, 2019-current)
   • NICHD T32 trainee (Oct 1, 2019-Sep 30, 2021)
   • Recipient of MSU postdoctoral excellence in teaching and/or mentoring award (PETMA, April 2022)
   • Frontiers in Reproduction: Molecular and Cellular Concepts and Applications. The University of Chicago Marine Biology Laboratory (April 30-June 12, 2022)
   • F32 from NICHD (Sep1, 2022-Aug 31, 2023)

Graduate Students (Current, PhD students)

1. Brooke M. Devries. Neuroscience Program (May 2021-current)
   • Trainee Professional Development Award (TPDA) from the Society for Neuroscience (Nov 2021)
   • NICHD T32 trainee (Dec 16, 2022-Dec 15, 2023)
2. Rachel Eck. Animal Science Program (March 2023-current)

Graduate Students (Graduated, PhD students)

1.     Thu Van Quynh Duong. College of Osteopathic Medicine. DO/PHD program (Oct 2018-May 2022)

• Recipient of the Women in Endocrinology Young Investigator Award (May 2021)
• College of Natural Science Continuation Fellowship (Fall semester 2021)
• Michigan Osteopathic Association hosts a Scientific Research Exhibit (SRE) Miscellaneous Category Award in Basic Science Research (Autumn 2021)

Medical Students

1. Rannan Kased. Sparrow Resident Fellow (February 2022-current)

Rotation Students

1.     Thu Van Quynh Duong. College of Osteopathic Medicine. DO/PHD program (Aug-Sep 2018)

2.     Rabail Khan. Neuroscience PhD Program (Aug-Dec 2019).

·       Fulbright Scholar from Pakistan

3. Brooke M. Devries. Neuroscience PhD Program (Virtual: July-Aug 2020, in person Jan-May 2021).
   • CNS Recruiting Fellowship for Year One
4. Kaitlyn Gordon. Neuroscience PhD Program (Aug-Dec 2020)
   • University Enrichment Fellowship

Undergraduate Students

1. Brooke M. Devries. Lyman Briggs undergraduate student (May 2018-Dec 2019)
   • Poster presentation: Brooke M Devries, Hanne M Hoffmann. Comparison and validation of two Gonadotropin-releasing hormone-promoter driven Cre expressing mice. (East Lansing, April 2019). Poster presented at
     • The Undergraduate Research and Arts forum at MSU
     • The 2019 Lyman Briggs Research Symposium MSUFCU poster session. Honorable Mention Award
   • NEU490 Undergraduate Research, Neuroscience Program. MSU (Fall 2019)
   • Accepted into the MSU Neuroscience PhD Program 2020
     • Recipient of the Rasmussen Doctoral Recruitment Award, MSU (2020)

2. Tulasi Talluri. Lyman Briggs undergraduate student (May 2018-May 2020)
   • Summer Research Fellowship from The Endocrine Society (2019-2020)
   • Poster presentation at the Undergraduate Research and Arts forum at MSU. Tulasi Talluri, Hanne M Hoffmann. Vax1 heterozygote mice have abnormal circadian rhythms which contribute to their poor fertility. (East Lansing, April 2019)
   • Medical Student at Oakland University William Beaumont School of Medicine (Rochester, Michigan). August 2020-current.
3. Gloria Parisa Yarandi. Lyman Briggs undergraduate student (August 2018-October 2018)
4. Muhammed Asad. Lyman Briggs undergraduate student (March 2019-January 2021)
   • ANS492 Undergraduate Research, Animal Science (Fall 2019)
5. Autumn Mclane-Svoboda. Mechanical/Biomedical Engineering undergraduate student (October 2019-August 2021)
   • EGR393 Cooperative Engineering Education (Undergraduate research, Spring 2020, Summer 2020, Fall 2020)
   • Poster presentation at Mid-Michigan Symposium for Undergraduate Research Experiences (Mid-SURE). Autumn McLane-Svoboda, Alexandra Yaw, Hanne M Hoffmann. The effect of shiftwork on the circadian rhythms in reproductive tissues. (Virtual conference, East Lansing, August 2020)
   • First place winner of oral presentation at the 12^thUniversity Undergraduate Research and Arts Forum (UURAF, MSU, 2021).
   • Graduate Student in the Biomedical Engineering program at MSU (August 2021-current)

6. Aneesh Sai Cherukuri. Lyman Briggs undergraduate student (October 2019-June 2021)
   • Alumni Distinguished Scholarship recipient, MSU (2018)
   • ANS492 Undergraduate Research, Animal Science (Fall 2020)
   • Poster presented at MARTS 2021 (University of Michigan, Michigan, October 2021), entitled “Promising novel drug targets to halt preterm labor through dual targeting of oxytocin and melatonin receptors”
7. Michael Ryan Hirschenberger. Lyman Briggs undergraduate student (March 2021-current)
8. Krystal Jang. Lyman Briggs undergraduate student (April 2021-current)
   • PSL490 Undergraduate Research (FS22, SS23)
9. Nicolette Ly. Biomedical Laboratory Science undergraduate student (May 2021-May 2022)
   • ANS492 Undergraduate Research, Animal Science (Spring 2022)
10. Mary Gardella. Animal Science undergraduate student. (August 2021-current)
    • ANS492 Undergraduate Research, Animal Science (Fall 2021), co-mentored with Dr. Jacobs (ANS)
    • First place winner of poster presentation at the University Undergraduate Research and Arts Forum (UURAF, MSU, April 13, 2022).
11. Grace Jaksen. Animal Science undergraduate student. (August 2021-current)
    • First place winner of virtual poster presentation at the 13^th Annual Animal Science Undergraduate Research Forum (ASURF, MSU, April 22, 2022)
12. Jennie Soule. Animal Science undergraduate student. (November 2021-August 2022)
13. Rachel Eck. Animal Science undergraduate student. (January 2022-current)
    • ANS492 Undergraduate Research, Animal Science (Spring 2022)
    • Recipient of the Reproductive and Developmental Sciences 2022 Summer Undergraduate Research Experience Fellowship (2022)
14. Kierra Jursch. Lyman Briggs undergraduate student. (September 2022-current)
    • Recipient of a Professional Assistant Ship from the Honors College (2022-2024).

Summer students

1. Fabiola Ramos. Undergraduate summer student from  the Antillean Adventist University, Mayaguez, Puerto Rico. May-August 2021 (in person), August 2021-May 2022 (virtual), May-August 2022 (in person)
   • 2021 and 2022, Supported by the “Bridge to the PhD in the Neuroscience Program”(BPNP), MSU. Program supported by ENDURE-NIEHS.
   • Poster presentation at Mid-Michigan Symposium for Undergraduate Research Experiences (Mid-SURE). Fabiola V. Ramos, Brooke M. Devries, Alexandra M. Yaw, Duong Nguyen, Hanne M. Hoffmann. “The transcription factor VAX1 is Required for Suprachiasmatic Nucleus Circadian Output and estrous cyclicity in in Female Mice (Virtual conference, East Lansing, July 2021)
2. Jessica Sora Lee. Medical student at Loyola University Chicago, Stritch School of Medicine. (May 2022-July 2022)
   • Recipient of the 2022 Endocrine Society Research Experiences for Graduate and Medical Students (REGMS) Fellowship.

LABORATORY TECHNICIANS AND LABORATORY MANAGERS

1. Duong Nguyen. Laboratory Technician. (August 2018-current)
2. Brooke M. Devries. Technical aid. (January 2020-June 2020)
3. Danalea Skarra. Clinical trial technical consultant (February 2020-November 2021)
4. Aneesh Sai Cherukuri. Technical aid. (July-August 2021)

GRADUATE STUDENT COMMITEES

Ph.D. committees

1. Thu Duong (Mentor Dr. Hoffmann) MSU DO-PhD program (BMS/BMB). Committee member (2018-2022).
2. Daniel Kwabena Marri (Mentor. Dr. Bhattacharya), MSU Biomedical Engineering Graduate Program. Committee member (2020-current).
3. Brooke Devries (Mentor Dr. Hoffmann), MSU Neuroscience Program. Committee chair (2021-current).
4. Alisson de Mota Santos (Mentor Dr. Pursley), MSU Animal Science. Committee member (2023-current).
5. Sanjana Venkataraman (Mentor Dr. Lonstein), MSU Neuroscience Program. Committee member (2023-current).

Master’s thesis committees

1. Samantha Bowden (Mentor Dr. Veenema), MSU Neuroscience Program. Committee member (2021-2022).
2. Eye Ampaiwan (Mentor Dr. Jacobs) MSU Animal Science. Committee member (2021-2022).
3. Anna Breithaupt (Mentor Dr. Jacobs) MSU Animal Science. Committee member (2021-current).
4. Kathryn Anne Baugh (mentor Dr. Siegford). MSU Animal Science. Committee member (2023-current).

External Program Representative for Comprehensive Exams

1. Jariel Ramirez-Virella. Neuroscience Program. Mentor Dr. Leininger. Comprehensive exam Nov 2021.
2. Hannah Rudolph. Neuroscience Program. Mentor Dr. Vogt. Comprehensive exam April 2022.

TRAINING COURSES

2008     FENSEB Animal handling course, Barcelona (Autonomous University Barcelona, Spain)

2009     Science history (Montpellier University 2, France)

2012     Ethics and Survival Skills (UC San Diego)

2015     Scientific Ethics (UC San Diego)

2017     Pathways to Scientific Teaching (January and February 2017, UC San Diego)

2017     Academic Laboratory Management & Leadership Symposium from Torrey Pines Training Consortium (February 2017, San Diego)

2018     Optimization of Research Mentoring Outcomes. Online course entitled CTSI X100-Optimizing the Practice of Mentoring. Course offered by the University of Minnesota.

2018     14-day writing trial program by the National Center for Faculty Development and Diversity

2018     The Iceman’s Run: Advanced NIH Grantsmanship and Personal Coaching Program for Winning NIH Grants - Webinar Series (MSU, September 20 – December 7)

2019     Write Winning Grants (One day workshop, January 2019, MSU)

2019     College of Agriculture and Natural Resources Mentoring Workshop (One day workshop, January 2019, MSU)

2019     MSU Academic Communications Fellowship and Training Program (Sep 2019-Dec 2019)

2020     The Iceman’s Run: Advanced NIH Grant Writing and Personal Coaching Program for Winning NIH Grants Spring 2020 - Webinar Series (MSU, February 27 – May 7, 2020)

2020     2020 Faculty Success Program offered by the National Center for Faculty Development and Diversity (Virtual program May 17^th to August 8^th, 2020)

2020     ASynchronous Program for Instructional Readiness (ASPIRE, self-paced online workshop on online teaching, MSU, MI)

LANGUAGES

• Danish: spoken, read and written (mother tongue)
• English: spoken, read and written (excellent)
• Spanish: spoken, read and written (very good)
• French: spoken, read and written (very good)
• German: spoken and read (basic)

/hoffmann/CV_ H Hoffmann 2019.docx