Publications

Duong TV, Yaw AM, Zhou G, Sina N, Cherukuri AS, Nguyen D, Cataldo K, Ly N, Sen A, Sempere L, Detrie C, Seiler R, Olomu IN, Cortese R, Long R, Hoffmann HM#.
Interaction between time-of-day and oxytocin efficacy in mice and humans with and without gestational diabetes.
Molecular Metabolism, 2025 (in press).
→ Landmark translational study revealing that oxytocin (Pitocin) efficacy and labor duration depend on circadian timing, particularly in gestational diabetes.

Cataldo K, Long R, Olomu I, Cortese R, Hoffmann HM.
Labor duration is defined by the time of day of labor induction.
medRxiv, 2024.
→ Clinical analysis of > 2,300 births showing morning inductions lead to shorter labors, demonstrating circadian gating of parturition.

Zhou G, Winn E, Kasten EP, Petroff MG, Hoffmann HM#.
Co-alterations of circadian clock gene transcripts in human placenta in preeclampsia.
Scientific Reports, 2022 12:17856. PMID 36284122.
→ First demonstration that disrupted CLOCK, NR1D2, and PER3 expression in human placenta underlies preeclampsia pathophysiology.

Zhou G, Fichorova RN, Holzman C, Chen B, Chang C, Kasten EP, Hoffmann HM#.
Placental circadian lincRNAs and spontaneous preterm birth.
Frontiers in Genetics, 2023. PMID 36712876.
→ Identified circadian-linked lincRNAs associated with spontaneous preterm birth, integrating genomics and perinatal biology.

Yaw AM, Gardella M, Jacobs J, Hoffmann HM.
Light quality and time in shelter modulate behavior and cortisol in the domestic cat (Felis catus).
iScience, 2025 28(6):112709. PMID 40546954.
→ Applied circadian principles to animal welfare, showing timed light exposure reduces feline stress and improves behavior.

Van Loh B, Yaw AM, Breuer JA, Jackson B, Nguyen D, Jang K, Ramos F, Ho EV, Cui LJ, Gilette DLM, Sempere L, Gorman MR, Tonsfeldt K, Mellon PL, Hoffmann HM#.
The transcription factor VAX1 in VIP neurons of the suprachiasmatic nucleus impacts circadian rhythm generation, depressive-like behavior, and the reproductive axis in a sex-specific manner in mice.
Frontiers in Endocrinology, 2023. PMID 38205198.
→ Reveals how VAX1 modulates SCN output and reproductive timing, linking mood, circadian rhythms, and fertility.

Tonsfeldt K, Mellon PL, Hoffmann HM#.
Circadian rhythms in the neuronal network timing the LH surge.
Endocrinology, 2022. PMID 34967900.
→ Defines how neuronal clock gene oscillations synchronize the luteinizing hormone surge essential for ovulation.

Sen A, Hoffmann HM#.
Role of core circadian clock genes in hormone release and target tissue sensitivity in the reproductive axis.
Molecular and Cellular Endocrinology, 2020 501:110655. PMID 31756424.
→ Highly cited review establishing the framework for circadian regulation of endocrine and reproductive function.

Hoffmann HM#, Mellon PL.
Regulation of GnRH gene expression.
In The GnRH Neuron and Its Control (eds. Herbison AE & Plant TM), Wiley, 2018.
→ Authoritative reference summarizing molecular control of GnRH transcription; cornerstone for neuroendocrine research.

Yaw AM, McLane-Svoboda AK, Hoffmann HM#.
Shiftwork and light-at-night negatively impact molecular and endocrine timekeeping in the female reproductive axis in humans and rodents.
International Journal of Molecular Sciences, 2021 22(1):324. PMID 33396885.
→ Demonstrates that light-at-night and shiftwork disrupt hormonal rhythms, linking environmental lighting to fertility.

Hoffmann HM#.
Boosting cognition with a hormone.
Science Perspective, 2022 377(661). PMID 36048939.
→ Invited Science commentary highlighting endocrine–circadian interactions in cognitive performance.