Our lab has a wide range of research interests ranging understanding ecological speciation to understanding the molecular mechanisms underlying insecticide resistance. We have started a new research area in understanding the biosynthesis of insect pheromones. Our research program uses tools in molecular and evolutionary biology to answer important and fundamental questions in entomology. We are applying our research into understanding and managing pesticide resistance in insect pests in the US, such as the Spotted Wing Drosophila and the Colorado potato beetle.
Current assignment: Teaching 25% | Research 75%
Teaching and mentoring are important aspects of my career objective. I feel enormous satisfaction when I helped a student understand a difficult topic or inspired them to learn more about a specific subject. I will be teaching a new 3-credit course entitled “Insect Physiology and Molecular Biology” that would be offered in alternate years starting from 2018. This course will cover broad topics in insect physiological systems and processes as well as emerging technologies in insect molecular biology such as CRISPR genome engineering.
The processes of adaptation and speciation have been conceptually intertwined since the time of Darwin, who suggested that adaptation to different environments leads to the evolution of new traits and at the same time, new species. To integrate the “how” of molecular mechanisms with the “why” of ecological relevance, my research focuses on the molecular basis of ecological adaptation and how traits which have dual roles in adaptation and mating behavior (dual traits) form at the molecular and genetic levels to cause reproductive isolation and the formation of new species (Chung & Carroll 2015). Being in an entomology department, I am also interested in understanding the biosynthesis on pheromones in different insect species and working with other groups in understanding the genomic and molecular basis of insecticide resistance in pest insects.
I am looking for creative and motivated students (undergrads and graduate students) as well as independent postdocs to join my research program. As a new assistant professor, I will work alongside you at the bench. This means that I will provide substantial training and mentorship, as well as being motivated to publish good research rapidly.
Insect Pheromone Evolution
Molecular Basis of Insecticide Resistance
Ecological Adaptation and Speciation
2017 - Present Assistant Professor, Department of Entomology, Michigan State University
2014-2016 - Research Specialist, Laboratory of Cellular and Molecular Biology, University of Wisconsin-Madison and Howard Hughes Medical Institute
2009-2014 - Research Associate, Laboratory of Cellular and Molecular Biology, University of Wisconsin-Madison and Howard Hughes Medical Institute
2004-2008 - Graduate Student, The University of Melbourne
2002 - Laboratory Technologist, Department of Neurology, Singapore General Hospital
Chiang YN, Tan KJ, Chung H, Lavrynenko O, Shevchenko A and Yew JY (2016). Steroid Hormone Signaling Is Essential for Pheromone Production and Oenocyte Survival. PLoS Genetics doi:10.1371/journal.pgen.1006126
Yassin A , Bastide H , Chung H , Veuille M, David JR, and Pool JE (2016). Ancient balancing selection at tan underlies female color dimorphism in Drosophila erecta. Nat Comm 7, Article number: 10400 doi:10.1038/ncomms10400
Yew JY and Chung H (2015). Insect pheromones: An overview of function, form, and discovery. Prog Lipid Res 59, 88-105 doi:10.1016/j.plipres.2015.06.001
Chung H* and Carroll SB* (2015). Wax, Sex and the Origin of Species: Dual roles of insect cuticular hydrocarbons in adaptation and mating. Bioessays 37, 822-30 doi: 10.1002/bies.201500014 *co-corresponding author
Chung H, Loehlin DW, Dufour HD, Vacarro K, Millar JG, and Carroll SB (2014). A single gene affects both ecological divergence and mate choice in Drosophila. Science 343, 1148-1151
Harrop T, Sztal T, Lumb C, Good RT, Daborn PJ, Batterham P* and Chung H* (2014). Evolutionary changes in gene expression, coding sequence and copy-number at the Cyp6g1 locus contribute to resistance to multiple insecticides in Drosophila. PLoS ONE e84879. doi:10.1371/journal.pone.0084879 *corresponding author
Sztal T, Chung H, Berger S, Currie PD, Batterham P, and Daborn PJ (2012). A cytochrome P450 conserved in insects is involved in cuticle formation. PLoS ONE 7(5):e36544
Chung H, Boey A, Lumb C, Willoughby L, Robin C, Batterham P and Daborn PJ (2011). Induction of a detoxification gene in Drosophila melanogaster requires an interaction between tissue specific enhancers and a novel cis-regulatory element. Insect Biochem Mol Biol 41, 863-71
Martin J, Chung H, Balakrishnan T, and Robin C (2010). Preliminary Physical Maps of the Chironomus Genome, with a Focus on Genes Potentially Involved in Response to Heavy Metals. In: Ferrington, L. C., Jr. (ed.). Proceedings of the XV International Symposium on Chironomidae. Chironomidae Research Group, University of Minnesota, Saint Paul, Minnesota, pp. 222-234.
Chung H, Sztal T, Pasricha S, Sridhar M, Batterham P, and Daborn PJ (2009). Characterization of Drosophila melanogaster cytochrome P450 genes. Proc Natl Acad Sci U S A 106, 5731–5736
Sztal T, Chung H, Gramzow L, Daborn PJ, Batterham P, and Robin C (2007). Two independent duplications forming the Cyp307a genes in Drosophila. Insect Biochem Mol Biol 37, 1044-1053
Chung H, Bogwitz MR, McCart C, Andrianopoulos A, ffrench-Constant RH, Batterham P, and Daborn PJ (2007). Cis-regulatory elements in the Accord retrotransposon result in tissue-specific expression of the Drosophilamelanogaster insecticide resistance gene Cyp6g1. Genetics 175, 1071–1077
Willoughby L, Chung H, Lumb C, Robin C, Batterham P, and Daborn PJ (2006). A comparison of Drosophila melanogaster detoxification gene induction responses for six insecticides, caffeine and Phenobarbital. Insect Biochem Mol Biol 36, 934-942.
Bogwitz MR, Chung H, Magoc L, Rigby S, Wong W, O’Keefe M, McKenzie JA, Batterham P, and Daborn PJ (2005). Cyp12a4 confers lufenuron resistance in a natural population of Drosophila melanogaster. Proc Natl Acad SciU S A 102, 12807-12812.